晚发性阿尔茨海默病的遗传风险因素会导致雌性tau蛋白病小鼠出现衰老。
Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice.
作者信息
Hensley-McBain Tiffany, Orr Miranda E
机构信息
McLaughlin Research Institute, Great Falls, MT 59405, USA; Touro College of Osteopathic Medicine, Great Falls, MT 59405, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; St. Louis VA Medical Center, St. Louis, MO, USA.
出版信息
Neuron. 2024 Dec 4;112(23):3811-3813. doi: 10.1016/j.neuron.2024.10.025.
PMID:39637835
Abstract
Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular senescence, a hallmark of aging, in a tau- and sex-dependent manner. Mechanistic insights into interactions among genetic risk, biological aging, and sex differences in LOAD are presented.
摘要
卡林等人报告称，晚发性阿尔茨海默病（LOAD）风险等位基因以tau和性别依赖的方式驱动细胞衰老，这是衰老的一个标志。文中还介绍了对LOAD中遗传风险、生物衰老和性别差异之间相互作用的机制性见解。
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