抑郁症状介导了饮食炎症指数与睡眠之间的关联：一项对2005 - 2014年美国国家健康与营养检查调查（NHANES）的横断面研究。

Depressive symptoms mediate the association between dietary inflammatory index and sleep: A cross-sectional study of NHANES 2005-2014.

作者信息

Ren Rui, Huang Runnian, Li Yi, Wang Wenxu, Ye Xingyue, Xi Linze, Zhang Ru, Peng Yang, Wang Difei

机构信息

Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China; Department of Health Statistics, School of Public Health, China Medical University, Shenyang, Liaoning 110122, China.

Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China.

出版信息

J Affect Disord. 2025 Mar 1;372:117-125. doi: 10.1016/j.jad.2024.12.020. Epub 2024 Dec 3.

DOI:10.1016/j.jad.2024.12.020

PMID:39638055

Abstract

BACKGROUND

Sleep pattern (sleep duration, trouble sleeping, sleep disorder) is associated with both energy density dietary inflammatory index (EDII) and depression. However, whether depression mediates the EDII-sleep pattern relationship is unclear.

METHODS

14,305 participants from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2014 were included in this study. Weighted multivariable logistic regression and mediated effect analysis were conducted to analyze the associations between EDII, depression and sleep pattern.

RESULTS

In the regression model with full confounding variables adjusted, the OR (95 % CI) for the association between EDII and sleep pattern was 2.11 (1.44, 3.08). Similarly, comparing the highest to the lowest EDII scores, the association with depression yielded an identical OR of 2.62 (1.89, 3.64). Mediation models showed depressive symptoms mediated 24.06 % of the EDII-sleep pattern link. Analysis by sleep pattern subtypes found depressive symptoms mediated 18.22 % for sleep duration, 30.53 % for sleep disorder (both with substantial direct EDII effects), and 93.73 % for trouble sleeping, where EDII's direct impact was not considerable.

CONCLUSION

Positive association of EDII with unhealthy sleep pattern is partly mediated by depression, and anti-inflammatory diet could be beneficial.

摘要

背景

睡眠模式（睡眠时间、睡眠困难、睡眠障碍）与能量密度膳食炎症指数（EDII）和抑郁症均相关。然而，抑郁症是否介导了EDII与睡眠模式之间的关系尚不清楚。

方法

本研究纳入了2005年至2014年美国国家健康与营养检查调查（NHANES）的14305名参与者。进行加权多变量逻辑回归和中介效应分析，以分析EDII、抑郁症与睡眠模式之间的关联。

结果

在调整了所有混杂变量的回归模型中，EDII与睡眠模式之间关联的OR（95%CI）为2.11（1.44，3.08）。同样，将最高EDII得分与最低EDII得分进行比较，与抑郁症的关联得出相同的OR为2.62（1.89，3.64）。中介模型显示，抑郁症状介导了EDII与睡眠模式之间联系的24.06%。按睡眠模式亚型分析发现，抑郁症状对睡眠时间的介导作用为18.22%，对睡眠障碍的介导作用为30.53%（两者均有显著的EDII直接效应），对睡眠困难的介导作用为93.73%，而EDII的直接影响不大。