来自毛果叶下珠的具有潜在细胞毒性的新对映-柯里烷型和对映-海松烷型二萜类化合物
New ent-cleistanthanes and ent-pimaras diterpenoids with potential cytotoxicity from Phyllanthus franchetianus H. Lév.
作者信息
Xin Ying, Niu Wang-Hui, Shang Jia-Huan, Li Na, Zhu Hong-Tao, Li Xiao-Nian, Yang Xing-Zhi, Zhang Ying-Jun
机构信息
State Key Laboratory of Phytochemistry & Natural Medicines (CAS), Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Chongqing Three Gorges Medical College, Chongqing 404120, China; University of Chinese Academy of Sciences, Beijing 100049, China.
State Key Laboratory of Phytochemistry & Natural Medicines (CAS), Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Fitoterapia. 2025 Jan;180:106334. doi: 10.1016/j.fitote.2024.106334. Epub 2024 Dec 3.
Seven diterpenoids including five ent-cleistanthanes (1, 2, 4-6) and two ent-pimaranes (3, 7) were isolated for the first time from the aerial part of Phyllanthus franchetianus H. Lév. Their structures were elucidated on the basis of the extensive spectroscopic analyses, single-crystal X-ray diffraction and ECD analysis. Phyllanthanes A-C (1-3) are new compounds. Notably, the ent-cleistanthanes 1 and 4-5 exhibited moderate cytotoxicity against five human cancer (HL-60, A549, HepG2, MDA-MB-231, SW480) (IC = 5.01-32.41 μM) and one normal BEAS-2B (IC = 20.45-24.33 μM) cell lines.
从毛果叶下珠的地上部分首次分离出七种二萜类化合物，包括五种对映贝壳杉烷型（1、2、4 - 6）和两种对映海松烷型（3、7）。通过广泛的光谱分析、单晶X射线衍射和电子圆二色光谱（ECD）分析确定了它们的结构。叶下珠烷A - C（1 - 3）为新化合物。值得注意的是，对映贝壳杉烷型化合物1和4 - 5对五种人类癌细胞系（HL - 60、A549、HepG2、MDA - MB - 231、SW480）（IC₅₀ = 5.01 - 32.41 μM）和一种正常BEAS - 2B细胞系（IC₅₀ = 20.45 - 24.33 μM）表现出中等细胞毒性。
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