Xia Yi-Fan, Zheng Jin-Hui, Li Yan-Song, Yu Ping, Liu Zhe, Zhou Jie, Fang Lei
School of Biological Sciences and Technology, University of Jinan, Jinan 250022, China.
School of Biological Sciences and Technology, University of Jinan, Jinan 250022, China; Jinan Engineering Research Center of plant-microbial interaction, Jinan 250022, China.
Fitoterapia. 2025 Mar;181:106392. doi: 10.1016/j.fitote.2025.106392. Epub 2025 Jan 12.
Two undescribed oxazole-containing diterpenoids (1-2) and a new diterpenoid (3) were isolated from the roots of Salvia miltiorrhiza. Their structures were elucidated by extensive HRESIMS and NMR spectroscopic analysis, and the absolute configurations of 1 and 3 were confirmed by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 represents the first example of an abietane diterpenoid with a benzo[d]oxazole unit fused in the ring B of the abietane skeleton. The cytotoxicity of 1-3 was evaluated against four human tumor cell lines (A549, MCF-7, HepG2, and PC-3), and 1-2 showed weak cytotoxic activities.
从丹参根部分离得到两个未描述的含恶唑二萜类化合物（1 - 2）和一个新的二萜类化合物（3）。通过广泛的高分辨电喷雾电离质谱（HRESIMS）和核磁共振（NMR）光谱分析阐明了它们的结构，并且通过比较计算的和实验的电子圆二色光谱（ECD）确定了1和3的绝对构型。化合物1是在枞酸骨架的B环中稠合有苯并[d]恶唑单元的枞酸型二萜类化合物的首个实例。评估了1 - 3对四种人类肿瘤细胞系（A549、MCF - 7、HepG2和PC - 3）的细胞毒性，1 - 2显示出较弱的细胞毒性活性。
