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1
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2
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引用本文的文献

1
The release of heparinase from the periplasmic space of Flavobacterium heparinum by three-step osmotic shock.
Appl Biochem Biotechnol. 1991 Aug;30(2):137-48. doi: 10.1007/BF02921681.

本文引用的文献

1
SULFUR METABOLISM OF AEROBACTER AEROGENES. I. A REPRESSIBLE SULFATASE.产气气杆菌的硫代谢。I. 一种可阻遏的硫酸酯酶。
Biochemistry. 1964 Feb;3:224-30. doi: 10.1021/bi00890a014.
2
The effect of sulphate assimilation on the induction of arylsulphatase synthesis in fungi.硫酸盐同化对真菌中芳基硫酸酯酶合成诱导的影响。
Biochem J. 1962 Jan;82(1):148-56. doi: 10.1042/bj0820148.
3
Heparinase production by Flavobacterium heparinum.肝素黄杆菌产生肝素酶。
Appl Environ Microbiol. 1981 Feb;41(2):360-5. doi: 10.1128/aem.41.2.360-365.1981.
4
An enzymatic system for removing heparin in extracorporeal therapy.
Science. 1982 Jul 16;217(4556):261-3. doi: 10.1126/science.7089564.
5
Differential anticoagulant activity of heparin fragments prepared using microbial heparinase.使用微生物肝素酶制备的肝素片段的抗凝活性差异
J Biol Chem. 1982 Jul 10;257(13):7310-3.
6
Mode of action of heparin lyase on heparin.肝素裂解酶对肝素的作用模式。
Biochim Biophys Acta. 1982 Apr 3;702(2):197-203. doi: 10.1016/0167-4838(82)90503-9.
7
Regulation of derepressed synthesis of arylsulfatase by tyramine oxidase in Salmonella typhimurium.鼠伤寒沙门氏菌中酪胺氧化酶对芳基硫酸酯酶去阻遏合成的调控。
J Bacteriol. 1981 Feb;145(2):796-802. doi: 10.1128/jb.145.2.796-802.1981.
8
An immobilized microbial heparinase for blood deheparinization.用于血液去肝素化的固定化微生物肝素酶。
Appl Biochem Biotechnol. 1984 Feb;9(1):41-55. doi: 10.1007/BF02798373.
9
Repression and induction of arylsulphatase synthesis in Aerobacter aerogenes.产气气杆菌中芳基硫酸酯酶合成的阻遏与诱导
Biochem J. 1964 Nov;93(2):373-8. doi: 10.1042/bj0930373.
10
Enzymic degradation of heparin. A sulphamidase and a sulphoesterase from Flavobacterium heparinum.肝素的酶促降解。来自肝素黄杆菌的一种硫酸酰胺酶和一种硫酸酯酶。
Biochem J. 1969 Jan;111(1):91-5. doi: 10.1042/bj1110091.

肝素黄杆菌中肝素酶和硫酸酯酶的硫调节

Sulfur regulation of heparinase and sulfatases in Flavobacterium heparinum.

作者信息

Cerbelaud E C, Conway L J, Galliher P M, Langer R S, Cooney C L

出版信息

Appl Environ Microbiol. 1986 Mar;51(3):640-6. doi: 10.1128/aem.51.3.640-646.1986.

DOI:10.1128/aem.51.3.640-646.1986
PMID:3963813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC238932/
Abstract

Sulfur regulation of heparinase synthesis and sulfatase synthesis was studied in Flavobacterium heparinum. Heparinase synthesis was strongly repressed by sulfate and L-cysteine, while the activity of this enzyme showed little or no inhibition by these compounds. Heparinase was synthesized in the absence of heparin when L-methionine was used as the sole sulfur source. The sulfatases produced by F. heparinum, which include the sulfatases involved in heparin catabolism, were also studied. At least some of the sulfatase activity was regulated by sulfur compounds in a manner similar to heparinase regulation. L-Cysteic acid and taurine were not suitable sulfur sources to support the growth of F. heparinum.

摘要

在肝素黄杆菌中研究了硫对肝素酶合成和硫酸酯酶合成的调节作用。肝素酶的合成受到硫酸盐和L-半胱氨酸的强烈抑制，而这些化合物对该酶的活性几乎没有抑制作用。当L-甲硫氨酸用作唯一硫源时，在没有肝素的情况下合成了肝素酶。还研究了肝素黄杆菌产生的硫酸酯酶，其中包括参与肝素分解代谢的硫酸酯酶。至少部分硫酸酯酶活性受硫化合物调节，其方式与肝素酶调节相似。L-磺基丙氨酸和牛磺酸不是支持肝素黄杆菌生长的合适硫源。