Yamada T, Ohira M, Hikishima H, Hashizume Y, Yamashita R, Kawaura Y, Iwa T
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 1):1004-9.
Seven patients with carcinomatous peritonitis were intraperitoneally treated with CDDP. This procedure does not require specific hydration transfusion and much less diuretic. According to Koyama and Saito's criteria, one patient showed complete response, 5 showed partial response and one no change. Following this therapy, 4 patients have lived for more than 6 months. Renal toxicity, which is considered to be the most serious side effect of CDDP, was not found. Alimentary symptoms (nausea, vomiting) were noted in all patients and myelosuppression and abdominal bleeding were recognized in a small number of patients. In conclusion, our method is considered to be advantageous in the treatment of carcinomatus peritonitis.
7例癌性腹膜炎患者接受了顺铂腹腔内治疗。该治疗方法无需特殊的水化输液，利尿剂用量也少得多。根据小山和斋藤的标准，1例患者显示完全缓解，5例部分缓解，1例无变化。经过该治疗后，4例患者存活超过6个月。未发现被认为是顺铂最严重副作用的肾毒性。所有患者均出现消化道症状（恶心、呕吐），少数患者出现骨髓抑制和腹腔出血。总之，我们的方法在癌性腹膜炎的治疗中被认为是有利的。
