Gerrard C S, Gerrity T R, Yeates D B
Arch Environ Health. 1986 Jan-Feb;41(1):11-5. doi: 10.1080/00039896.1986.9935759.
Although the effect of deposition pattern of an inhaled aerosol upon subsequent mucociliary clearance is well recognized, the influence of lung size on the rate of clearance has not been clearly defined. To examine the relationships of lung size in terms of the forced vital capacity (FVC) and aerosol deposition pattern to the rate of mucociliary clearance, we measured lung retention of an inhaled 8-micron aerosol for 120 min using a gamma camera in 13 healthy nonsmoking volunteers. The deposition pattern of the inhaled aerosol was defined in terms of the initial skew of the distribution of retained activity within the right lung (skew) and the percent retained at 24 hr (R24). Multiple regression analysis showed that FVC was responsible for approximately 36% of the variability in bronchial retention with time, with a lesser contribution from variations in deposition pattern (skew and R24). Mucociliary clearance was significantly slower (i.e., greater bronchial retention) in male subjects than in female subjects which can probably be attributed to the differences in FVC. Variations in lung sizes as well as deposition pattern should therefore be considered when making between subject comparisons of the mucociliary clearance rate.
尽管吸入气雾剂的沉积模式对随后的黏液纤毛清除率的影响已得到充分认识，但肺大小对清除率的影响尚未明确界定。为了研究以用力肺活量（FVC）衡量的肺大小和气溶胶沉积模式与黏液纤毛清除率之间的关系，我们使用γ相机在13名健康不吸烟志愿者中测量了吸入的8微米气雾剂在肺内120分钟的滞留情况。吸入气雾剂的沉积模式根据右肺内滞留活性分布的初始偏斜度（偏斜）和24小时时的滞留百分比（R24）来定义。多元回归分析表明，FVC约占支气管滞留随时间变化的36%，沉积模式（偏斜和R24）的变化贡献较小。男性受试者的黏液纤毛清除明显较慢（即支气管滞留更多），这可能归因于FVC的差异。因此，在进行受试者间黏液纤毛清除率比较时，应考虑肺大小以及沉积模式的变化。
