Garrard C S, Gerrity T R, Schreiner J F, Yeates D B
Chest. 1981 Dec;80(6 Suppl):840-2. doi: 10.1378/chest.80.6.840.
Thirteen healthy nonsmoking volunteers inhaled an 8.1 micrometers (MMAD) radioaerosol on two occasions. Aerosol deposition pattern within the right lung, as recorded by a gamma camera, was expressed as the 3rd and 4th moments of the distribution histogram (skew and kurtosis) of radioactivity during the first ten minutes after aerosol inhalation. Deposition pattern was also expressed as the percentage of deposited activity retained within the lung at 24 hr (24 hr % retention) and found to be significantly correlated with measures of skew (P less than 0.001). Tests of pulmonary function (FEV1, FVC, and MMFR) were significantly correlated with skew. Correlations were also demonstrated for these pulmonary function tests with 24 hr % retention but at lower levels of significance. Results indicate that changes in measures of forced expiratory airflow in healthy human volunteers influence deposition pattern and that the skew of the distribution of inhaled radioactivity may provide an acceptable index of deposition pattern.
13名健康的非吸烟志愿者分两次吸入了一种空气动力学直径为8.1微米的放射性气溶胶。用γ相机记录右肺内的气溶胶沉积模式，以吸入气溶胶后最初10分钟内放射性分布直方图的第3和第4矩（偏度和峰度）来表示。沉积模式也以24小时时肺内保留的沉积活性百分比（24小时保留率）来表示，并且发现其与偏度测量值显著相关（P小于0.001）。肺功能测试（FEV1、FVC和MMFR）与偏度显著相关。这些肺功能测试与24小时保留率之间也显示出相关性，但显著性水平较低。结果表明，健康人类志愿者用力呼气气流测量值的变化会影响沉积模式，并且吸入放射性分布的偏度可能提供一个可接受的沉积模式指标。
