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Putting bacteria in alarm.

作者信息

Loris Remy

机构信息

Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.

VIB-VUB Center for Structural Biology, Brussels, Belgium.

出版信息

Nat Chem Biol. 2025 Feb;21(2):158-159. doi: 10.1038/s41589-024-01788-x.

DOI:10.1038/s41589-024-01788-x
PMID:39639165
Abstract
摘要

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本文引用的文献

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Mechanisms of neutralization of toxSAS from toxin-antitoxin modules.来自毒素-抗毒素模块的toxSAS的中和机制。
Nat Chem Biol. 2025 Feb;21(2):182-192. doi: 10.1038/s41589-024-01630-4. Epub 2024 Jun 4.
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Toxin-antitoxin systems as mediators of phage defence and the implications for abortive infection.毒素-抗毒素系统作为噬菌体防御的介体及其对流产感染的影响。
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Direct activation of a bacterial innate immune system by a viral capsid protein.
病毒衣壳蛋白直接激活细菌固有免疫系统。
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Biology and evolution of bacterial toxin-antitoxin systems.细菌毒素-抗毒素系统的生物学与进化。
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RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis.RelA-SpoT 同源毒素使 tRNA 的 CCA 末端焦磷酸化,从而抑制蛋白质合成。
Mol Cell. 2021 Aug 5;81(15):3160-3170.e9. doi: 10.1016/j.molcel.2021.06.005. Epub 2021 Jun 25.
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An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp.一种细菌间毒素通过合成 (p)ppApp 来抑制靶细胞生长。
Nature. 2019 Nov;575(7784):674-678. doi: 10.1038/s41586-019-1735-9. Epub 2019 Nov 6.
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AtaT blocks translation initiation by N-acetylation of the initiator tRNA.ATA1 可通过起始 tRNA 的 N-乙酰化来阻断翻译起始。
Nat Chem Biol. 2017 Jun;13(6):640-646. doi: 10.1038/nchembio.2346. Epub 2017 Apr 3.
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A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA.一种沙门氏菌毒素通过tRNA的乙酰化促进持留菌形成。
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The RelA/SpoT homolog (RSH) superfamily: distribution and functional evolution of ppGpp synthetases and hydrolases across the tree of life.RelA/SpoT 同源物 (RSH) 超家族:ppGpp 合成酶和水解酶在生命之树中的分布和功能进化。
PLoS One. 2011;6(8):e23479. doi: 10.1371/journal.pone.0023479. Epub 2011 Aug 9.
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Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA.肠致病性相关蛋白 VapC 通过切割起始 tRNA 抑制翻译。
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7403-7. doi: 10.1073/pnas.1019587108. Epub 2011 Apr 18.