Li Jinqiao, Li Xiaoxia, Fu Yueyue, Meng Hongbin, Xu Dan, Hou Wenyi
Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, China.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2433304. doi: 10.1080/21645515.2024.2433304. Epub 2024 Dec 5.
Multiple myeloma (MM) is a malignant, clonal proliferative disease of plasma cells that remains incurable. This paper aims to analyze the current research status and emerging trends in immunotherapy for MM through bibliometric methods, thereby providing valuable references and guidance for future research and clinical practice. This study presents a bibliometric analysis of 1,018 English-language publications related to MM immunotherapy, which were published in the Web of Science (WoS) Core Collection database from 2013 to 2023. VOSviewer and CiteSpace were employed to visualize the research hotspots and trends within the field of MM immunotherapy. The United States had the highest number of publications ( = 432, 42.44%), followed by China ( = 177, 17.39%). Harvard University was the institution with the most publications ( = 85), while Anderson KC ( = 27) was the most prolific researcher in the field. The highly cited literature mainly focuses on the treatment regimen based on daratumumab, the application of BCMA CAR-T therapy and the management of relapsed/refractory MM (RRMM), which represent the current research hotspots in this field. Burst detection highlights that bispecific antibodies and preclinical activity as key areas of interest. The cooperation among countries, institutions, and authors in this field should be strengthened. The treatment regimen utilizing daratumumab, the implementation of BCMA CAR-T therapy, and the management of RRMM represent significant research focal points in this field. Additionally, the development and application of bispecific antibodies have emerged as a frontier in recent years.
多发性骨髓瘤(MM)是一种恶性的浆细胞克隆增殖性疾病,仍然无法治愈。本文旨在通过文献计量学方法分析MM免疫治疗的当前研究现状和新趋势,从而为未来的研究和临床实践提供有价值的参考和指导。本研究对2013年至2023年发表在科学网(WoS)核心合集数据库中的1018篇与MM免疫治疗相关的英文出版物进行了文献计量分析。使用VOSviewer和CiteSpace对MM免疫治疗领域的研究热点和趋势进行可视化。美国的出版物数量最多(=432,42.44%),其次是中国(=177,17.39%)。哈佛大学是发表论文最多的机构(=85),而安德森·KC(=27)是该领域最多产的研究者。高被引文献主要集中在基于达雷妥尤单抗的治疗方案、BCMA CAR-T疗法的应用以及复发/难治性MM(RRMM)的管理,这些代表了该领域当前的研究热点。突变检测突出显示双特异性抗体和临床前活性是关键的研究兴趣领域。应加强该领域国家、机构和作者之间的合作。使用达雷妥尤单抗的治疗方案、BCMA CAR-T疗法的实施以及RRMM的管理是该领域重要的研究重点。此外,双特异性抗体的开发和应用近年来已成为一个前沿领域。