• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

线粒体转移研究指南。

A guide to studying mitochondria transfer.

机构信息

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.

Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Nat Cell Biol. 2023 Nov;25(11):1551-1553. doi: 10.1038/s41556-023-01246-1.

DOI:10.1038/s41556-023-01246-1
PMID:37853133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11610514/
Abstract

Mitochondria can shuttle between adjacent cells or travel to distant organs by breaking away from the parent cell and entering circulation. Here, we briefly review the state of the mitochondria transfer field and discuss a methodological framework for studying mitochondria transfer.

摘要

线粒体可以通过脱离母细胞并进入循环系统在相邻细胞之间穿梭或迁移到远处的器官。在这里，我们简要回顾了线粒体转移领域的现状，并讨论了研究线粒体转移的方法学框架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/395e/11610514/efcd5fe15e91/nihms-2037194-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/395e/11610514/efcd5fe15e91/nihms-2037194-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/395e/11610514/efcd5fe15e91/nihms-2037194-f0001.jpg

相似文献

1
A guide to studying mitochondria transfer.线粒体转移研究指南。
Nat Cell Biol. 2023 Nov;25(11):1551-1553. doi: 10.1038/s41556-023-01246-1.
2
Hypothermia promotes tunneling nanotube formation and the transfer of astrocytic mitochondria into oxygen-glucose deprivation/reoxygenation-injured neurons.低温促进隧道纳米管的形成，并将星形胶质细胞的线粒体转移到氧葡萄糖剥夺/复氧损伤的神经元中。
Brain Res. 2024 May 15;1831:148826. doi: 10.1016/j.brainres.2024.148826. Epub 2024 Feb 23.
3
Versatility of Preprotein Transfer from the Cytosol to Mitochondria.细胞质到线粒体前蛋白转移的多功能性。
Trends Cell Biol. 2019 Jul;29(7):534-548. doi: 10.1016/j.tcb.2019.03.007. Epub 2019 Apr 26.
4
MERLIN: A BRET-Based Proximity Biosensor for Studying Mitochondria-ER Contact Sites.MERLIN：一种基于 BRET 的临近传感器，用于研究线粒体-内质网接触位点。
Methods Mol Biol. 2022;2525:197-205. doi: 10.1007/978-1-0716-2473-9_14.
5
[Phosphatidylcholine transfer between liposomes and mitochondria. Testing system for the study of specific phospholipid exchange].[脂质体与线粒体之间的磷脂酰胆碱转移。用于研究特定磷脂交换的测试系统]
Acta Biol Med Ger. 1975;34(2):241-6.
6
Mitochondria: emerging therapeutic strategies for oocyte rescue.线粒体：卵母细胞拯救的新兴治疗策略。
Reprod Sci. 2022 Mar;29(3):711-722. doi: 10.1007/s43032-021-00523-4. Epub 2021 Mar 12.
7
Pronounced segregation of donor mitochondria introduced by bovine ooplasmic transfer to the female germ-line.通过牛卵细胞质转移将供体线粒体明显分离到雌性生殖系中。
Biol Reprod. 2010 Mar;82(3):563-71. doi: 10.1095/biolreprod.109.080564. Epub 2009 Dec 2.
8
Xenogenic transfer of isolated murine mitochondria into human rho0 cells can improve respiratory function.将分离的小鼠线粒体异种移植到人类rho0细胞中可改善呼吸功能。
Rejuvenation Res. 2007 Dec;10(4):561-70. doi: 10.1089/rej.2007.0575.
9
Intracellular Energy-Transfer Networks and High-Resolution Respirometry: A Convenient Approach for Studying Their Function.细胞内能量转移网络和高分辨率呼吸测量法：研究其功能的便捷方法。
Int J Mol Sci. 2018 Sep 26;19(10):2933. doi: 10.3390/ijms19102933.
10
Exploring the limitations of mitochondrial dye as a genuine horizontal mitochondrial transfer surrogate.探究线粒体染料作为真正水平线粒体转移替代物的局限性。
Commun Biol. 2024 Mar 7;7(1):281. doi: 10.1038/s42003-024-05964-6.

引用本文的文献

1
Mitochondria transplanted adipose-derived stem cells/decellularized adipose tissue hydrogel for adipose tissue regeneration.线粒体移植脂肪来源干细胞/脱细胞脂肪组织水凝胶用于脂肪组织再生。
Mater Today Bio. 2025 Aug 13;34:102193. doi: 10.1016/j.mtbio.2025.102193. eCollection 2025 Oct.
2
Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation.肥胖相关巨噬细胞通过促进线粒体碎片化来决定脂肪干细胞的铁死亡和内脏脂肪功能障碍。
Nat Commun. 2025 Aug 14;16(1):7564. doi: 10.1038/s41467-025-62690-1.
3
Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer.

本文引用的文献

1
The power and potential of mitochondria transfer.线粒体转移的力量和潜力。
Nature. 2023 Nov;623(7986):283-291. doi: 10.1038/s41586-023-06537-z. Epub 2023 Nov 8.
2
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired.当溶酶体功能受损时，线粒体通过细胞外囊泡被分泌。
Nat Commun. 2023 Aug 18;14(1):5031. doi: 10.1038/s41467-023-40680-5.
3
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood.膳食脂质抑制线粒体向巨噬细胞的转移，从而将脂肪细胞衍生的线粒体转移到血液中。
一氧化氮预处理的工程化细胞外囊泡通过线粒体转移恢复急性肾损伤中的生物能量学。
Theranostics. 2025 Apr 13;15(11):5499-5517. doi: 10.7150/thno.113741. eCollection 2025.
4
Near Infrared-Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model.近红外介导的细胞内烟酰胺腺嘌呤二核苷酸递送增强肌肉功能障碍模型中的线粒体功能和稳定性
Adv Sci (Weinh). 2025 Mar;12(12):e2415303. doi: 10.1002/advs.202415303. Epub 2025 Jan 31.
5
Recommendations for mitochondria transfer and transplantation nomenclature and characterization.线粒体转移与移植的命名及特征描述建议
Nat Metab. 2025 Jan;7(1):53-67. doi: 10.1038/s42255-024-01200-x. Epub 2025 Jan 16.
6
Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment.靶向线粒体转移：心血管疾病治疗的新前沿。
J Transl Med. 2024 Dec 31;22(1):1160. doi: 10.1186/s12967-024-05979-x.
7
The Role and Applied Value of Mitochondria in Glioma-Related Research.线粒体在胶质瘤相关研究中的作用及应用价值
CNS Neurosci Ther. 2024 Dec;30(12):e70121. doi: 10.1111/cns.70121.
8
Levodopa-induced dyskinesia: brain iron deposition as a new hypothesis.左旋多巴诱发的运动障碍：脑铁沉积作为一种新假说。
Biometals. 2024 Dec;37(6):1307-1323. doi: 10.1007/s10534-024-00628-8. Epub 2024 Aug 30.
9
Horizontal mitochondrial transfer as a novel bioenergetic tool for mesenchymal stromal/stem cells: molecular mechanisms and therapeutic potential in a variety of diseases.横向线粒体转移作为一种新型的间充质基质/干细胞生物能量工具：在多种疾病中的分子机制和治疗潜力。
J Transl Med. 2024 May 24;22(1):491. doi: 10.1186/s12967-024-05047-4.
10
Mitochondrial dysfunction: mechanisms and advances in therapy.线粒体功能障碍：机制与治疗进展。
Signal Transduct Target Ther. 2024 May 15;9(1):124. doi: 10.1038/s41392-024-01839-8.
Cell Metab. 2022 Oct 4;34(10):1499-1513.e8. doi: 10.1016/j.cmet.2022.08.010. Epub 2022 Sep 6.
4
Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases.线粒体转移/移植：一种新兴的针对多种疾病的治疗方法。
Cell Biosci. 2022 May 19;12(1):66. doi: 10.1186/s13578-022-00805-7.
5
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.受损线粒体的排出和巨噬细胞的清除确保了棕色脂肪组织中有效的产热作用。
Cell Metab. 2022 Apr 5;34(4):533-548.e12. doi: 10.1016/j.cmet.2022.02.016. Epub 2022 Mar 18.
6
Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells.细胞间纳米管介导癌细胞和免疫细胞之间的线粒体运输。
Nat Nanotechnol. 2022 Jan;17(1):98-106. doi: 10.1038/s41565-021-01000-4. Epub 2021 Nov 18.
7
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes.基于细胞外囊泡的从能量应激脂肪细胞到其他器官的线粒体的转运。
Cell Metab. 2021 Sep 7;33(9):1853-1868.e11. doi: 10.1016/j.cmet.2021.08.002. Epub 2021 Aug 20.
8
Isolation and analysis methods of extracellular vesicles (EVs).细胞外囊泡（EVs）的分离与分析方法。
Extracell Vesicles Circ Nucl Acids. 2021;2(1):80-103. doi: 10.20517/evcna.2021.07. Epub 2020 Mar 30.
9
Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs.选择性地将线粒体蛋白包装到细胞外囊泡中可以防止线粒体 DAMPs 的释放。
Nat Commun. 2021 Mar 30;12(1):1971. doi: 10.1038/s41467-021-21984-w.
10
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome.线粒体来源的微囊泡是一种新型的细胞外囊泡群体，在唐氏综合征中发生改变。
Sci Adv. 2021 Feb 12;7(7). doi: 10.1126/sciadv.abe5085. Print 2021 Feb.