Asadi Anoosha, Barati Fatemeh, Nakhaee Alireza, Jahantigh Danial, Hashemi Seyed-Mehdi, Taheri Mohsen, Bahari Gholamreza
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.
Per Med. 2024;21(6):373-383. doi: 10.1080/17410541.2024.2435800. Epub 2024 Dec 5.
In this study, we examined the polymorphisms of (rs13252298, rs1456315), (rs4848320) (rs7158663), (rs7853346) genes in BC patients and compared it with healthy individuals in an Iranian population.
The assessment of genetic polymorphisms was conducted using PCR - RFLP and PCR-Tetra ARMS methods.
RESULTS & CONCLUSION: The results showed that Codominant, Dominant and G allele of rs13252298 polymorphism and Dominant of rs1456315 polymorphism are correlated with increased risk of BC. The CT and TT genotype and Dominant and T allele of rs4848320 polymorphism is also a risk factor in the study population. The genotype AA, dominant, recessive and A allele of rs7158663 polymorphism and also CC genotype of rs7853346 polymorphism increase the risk of BC.
在本研究中，我们检测了乳腺癌（BC）患者中（rs13252298、rs1456315）、（rs4848320）、（rs7158663）、（rs7853346）基因的多态性，并将其与伊朗人群中的健康个体进行比较。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和聚合酶链反应-四引物扩增受阻突变系统（PCR-Tetra ARMS）方法对基因多态性进行评估。
结果显示，rs13252298多态性的共显性、显性和G等位基因以及rs1456315多态性的显性与BC风险增加相关。rs4848320多态性的CT和TT基因型以及显性和T等位基因也是研究人群中的一个风险因素。rs7158663多态性的AA基因型、显性、隐性和A等位基因以及rs7853346多态性的CC基因型会增加BC风险。
