Hu Yuan-Yuan, Chen Rui, Li Xue-Feng, Niu Yu-Ming
Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, P.R. China.
Department of Stomatology, Taihe Hospital, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Oncol Lett. 2025 Sep 4;30(5):511. doi: 10.3892/ol.2025.15257. eCollection 2025 Nov.
The long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) polymorphism is associated with cancer risk, however, the results have been inconsistent. Therefore, the present meta-analysis aimed to explore the associations between MEG3 polymorphisms and cancer risk. Online databases were searched and reviewed up to December 2024 for eligible studies. Odds ratios (ORs) and corresponding 95% CIs were calculated to assess the underlying association with genetic models. Furthermore, heterogeneity tests, sensitivity and accumulative analysis and publication bias assessment were conducted to evaluate the robustness of the results. There were 24 publications comprising 45 independent case-control studies included in the present meta-analysis. The pooled results revealed a markedly increased cancer risk with the A allele of the MEG3 rs7158663 G>A variant [for example, GA + AA vs. GG (OR, 1.34; 95% CI, 1.14-1.56; P<0.01; I=78.8%)] and consistent findings across several subgroups such as in in both Hardy-Weinberg Equilibrium (HWE-yes and HWE-no groups, and both in East Asian and Middle Eastern individuals. Furthermore, a notable association was observed between rs11160608 A>C and cancer risk [for example, AC + CC vs. AA (OR, 1.16; 95% CI, 1.01-1.33; P=0.04; I=2.7%)], particularly in East Asian populations. No notable associations were identified for other polymorphic loci and cancer risk. In summary, the present meta-analysis suggested that the MEG3 rs7158663 G>A polymorphism may be a risk factor for cancer development.
长链非编码RNA（lncRNA）母系表达基因3（MEG3）多态性与癌症风险相关，然而，结果并不一致。因此，本荟萃分析旨在探讨MEG3多态性与癌症风险之间的关联。检索并回顾了截至2024年12月的在线数据库，以查找符合条件的研究。计算优势比（OR）和相应的95%置信区间（CI），以评估与遗传模型的潜在关联。此外，进行了异质性检验、敏感性和累积分析以及发表偏倚评估，以评估结果的稳健性。本荟萃分析纳入了24篇出版物，包括45项独立的病例对照研究。汇总结果显示，MEG3 rs7158663 G>A变异的A等位基因使癌症风险显著增加[例如，GA + AA与GG相比（OR，1.34；95% CI，1.14 - 1.56；P<0.01；I = 78.8%）]，并且在几个亚组中结果一致，如在哈迪-温伯格平衡（HWE-是组和HWE-否组）以及东亚和中东个体中均是如此。此外，观察到rs11160608 A>C与癌症风险之间存在显著关联[例如，AC + CC与AA相比（OR，1.16；95% CI，1.01 - 1.33；P = 0.04；I = 2.7%）]，特别是在东亚人群中。未发现其他多态性位点与癌症风险之间存在显著关联。总之，本荟萃分析表明，MEG3 rs7158663 G>A多态性可能是癌症发生的一个危险因素。
