PAX8AS1(rs4848320 C > T、rs1110839 G > T 和 rs6726151 T > G)和 MEG3(rs7158663)基因多态性与非霍奇金淋巴瘤风险的相关性。
Association between PAX8AS1 (rs4848320 C > T, rs1110839 G > T, and rs6726151 T > G) and MEG3 (rs7158663) gene polymorphisms and non-Hodgkin lymphoma risk.
机构信息
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2022;41(11):1174-1186. doi: 10.1080/15257770.2022.2104870. Epub 2022 Aug 8.
Long non-coding RNA (lncRNA) PAX8 antisense RNA 1 (PAX8AS1) and Maternal-expressed gene 3 (MEG3) contribute to the pathogenesis of various malignancies including non-Hodgkin lymphoma (NHL). In this study, we aimed to examine the possible association of polymorphisms of PAX8 and MEG3 and the risk NHL. A total of 175 patients and 175 healthy subjects were genotyped by PCR-RFLP and Tetra-Arms PCR assays. Results demonstrated rs4848320 C > T and rs6726151 T > G of PAX8AS1 and rs7158663 of MEG3 play a potential role in the susceptibility of NHL and PAX8AS1 rs1110839 T > G variant was associated with decreased risk of NHL. Haplotype analysis of rs1110839, rs4848320, and rs6726151 demonstrated GCG haplotype is associated with increased risk of lymphoma and TTG, TTT, and GTT haplotypes are related to decreased lymphoma susceptibility.
长链非编码 RNA（lncRNA）PAX8 反义 RNA 1（PAX8AS1）和母系表达基因 3（MEG3）有助于各种恶性肿瘤的发病机制，包括非霍奇金淋巴瘤（NHL）。在这项研究中，我们旨在研究 PAX8 和 MEG3 的多态性与 NHL 风险的可能关联。通过 PCR-RFLP 和四臂 PCR 分析对 175 例患者和 175 例健康受试者进行了基因分型。结果表明，PAX8AS1 的 rs4848320C>T 和 rs6726151T>G 以及 MEG3 的 rs7158663 可能与 NHL 的易感性有关，PAX8AS1 rs1110839T>G 变体与 NHL 风险降低有关。rs1110839、rs4848320 和 rs6726151 的单体型分析表明，GCG 单体型与淋巴瘤风险增加有关，TTT、TTT 和 GTT 单体型与淋巴瘤易感性降低有关。
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