Tamura Mitsuyoshi, Hirano Shigeki, Kitayama Yoshihisa, Morooka Marie, Suichi Tomoki, Shibuya Kazumoto, Higuchi Yoshinori, Kuwabara Satoshi
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
eNeurologicalSci. 2024 Nov 17;37:100536. doi: 10.1016/j.ensci.2024.100536. eCollection 2024 Dec.
The efficacy of deep brain stimulation (DBS) in treating tremor symptoms in cerebellar disorders remains unclear.
A 47-year-old woman presented with neck and arm tremor and ataxic speech/gait after four days of >40 °C fever due to septic shock attributed to lithiasis-pyelonephritis. Left ventral intermediate nucleus thalamus DBS alleviated contralateral postural arm tremor, although the action tremor and terminal oscillation remained unchanged.
To our knowledge, this is the first report of thalamic DBS for hyperthermia-induced cerebellar dysfunction. Patients with postural tremor resulting from cerebellar damage can benefit from thalamic DBS, leading to improved activities of daily living.
脑深部电刺激（DBS）治疗小脑疾病震颤症状的疗效尚不清楚。
一名47岁女性，因结石性肾盂肾炎导致脓毒性休克，在40℃以上发热4天后出现颈部和手臂震颤以及共济失调性言语/步态。左侧丘脑腹中间核DBS减轻了对侧姿势性手臂震颤，尽管动作性震颤和终末摆动未改变。
据我们所知，这是丘脑DBS治疗高热诱发的小脑功能障碍的首例报告。因小脑损伤导致姿势性震颤的患者可从丘脑DBS中获益，从而改善日常生活活动能力。
