Isono Wataru, Maruyama Masanori
Department of Obstetrics and Gynaecology, University Hospital Mizonokuchi, Teikyo University School of Medicine, 5-1-1, Futago, Takatsu-Ku, Kawasaki, Kanagawa 213-8507, Japan.
Department of Obstetrics and Gynecology, Maruyama Memorial General Hospital, 2-10-5, Honchou, Iwatsuki-ku, Saitama City, Saitama 339-8521, Japan.
Eur J Obstet Gynecol Reprod Biol X. 2024 Nov 14;24:100354. doi: 10.1016/j.eurox.2024.100354. eCollection 2024 Dec.
To reduce the damage of uterine endometrium caused during hysteroscopic myomectomy (HM) for reproductive aged patients, a new uterine endometrium preservation hysteroscopic myomectomy (UEP-HM) has been developed. In this study, we introduced this technique with comparing to the conventional hysteroscopic myomectomy (C-HM).
The data from 94 patients aged 42 or younger who underwent HM (38 cases with UEP-HM and 56 cases with C-HM) for treating single Type 1 or Type 2 submucosal leiomyoma (SL) were analysed retrospectively for comparing the characteristics of both patient and target SL. In this process, we defined the operation time 60 min or over as the longtime operation (LTO) and the SM sized 3 cm or over as the large submucosal leiomyoma (LSL) for detecting the influential factors, including this procedure, on the difficulty of HM. For assisting the prediction of operation time (OT), we investigated the relationship between the OT and the cube of average diameter (AD) of target SL referring with some past reports.
Although when comparing UEP and control groups, parity, AD, the number of patients with Type 2 SL, OT, and the number of infertile patients showed significant difference, in the multivariate analysis only LSL showed the significant influence on the possibility of LTO. Next, we compared OT/Cube of AD, which calculated by dividing OT by the cube of AD for evaluating OT from the target SL size and confirmed that there was no difference in those 2 groups (3.7 ± 3.0 (95 %CI: 0.9 - 13.3, n = 38) vs. 3.9 ± 3.2 (95 %CI: 0.4 - 17.3, n = 56), p = 0.79).
The new UEP-HM can become an alternative method of C-HM without procedure-specific difficulty. In the future, to investigate the prognosis of this procedure, more patients and further analyses should be accumulated.
为减少宫腔镜子宫肌瘤切除术(HM)对生育期患者子宫内膜造成的损伤,研发了一种新的保留子宫内膜的宫腔镜子宫肌瘤切除术(UEP-HM)。在本研究中,我们介绍了该技术,并与传统宫腔镜子宫肌瘤切除术(C-HM)进行比较。
回顾性分析94例42岁及以下因治疗单发1型或2型黏膜下平滑肌瘤(SL)而接受HM(38例行UEP-HM,56例行C-HM)患者的数据,以比较患者及目标SL的特征。在此过程中,我们将手术时间60分钟及以上定义为长时间手术(LTO),将直径3cm及以上的SM定义为大黏膜下平滑肌瘤(LSL),以检测包括该手术方式在内的影响HM难度的因素。为辅助预测手术时间(OT),参考既往一些报道,我们研究了OT与目标SL平均直径(AD)的立方之间的关系。
虽然比较UEP组和对照组时,产次、AD、2型SL患者数量、OT以及不孕患者数量存在显著差异,但多因素分析显示仅LSL对LTO的可能性有显著影响。接下来,我们比较了OT/AD³,即OT除以AD³,用于从目标SL大小评估OT,结果证实两组之间无差异(3.7±3.0(95%CI:0.9 - 13.3,n = 38) vs. 3.9±3.2(95%CI:0.4 - 17.3,n = 56),p = 0.79)。
新的UEP-HM可成为C-HM的替代方法,且不存在特定手术难度。未来,为研究该手术的预后,应积累更多患者并进行进一步分析。