Jeyaraman Madhan, Jeyaraman Naveen, Ram Pothuri Rishi, Venkatasalam Ravichandran, Yadav Sankalp
Orthopedics, ACS Medical College and Hospital, Dr. MGR Educational and Research Institute, Chennai, IND.
Orthopedics and Trauma, Sanjay Gandhi institute of Trauma and Orthopedics, Bengaluru, IND.
Cureus. 2023 Sep 18;15(9):e45435. doi: 10.7759/cureus.45435. eCollection 2023 Sep.
Due to the Industry 4.0 and Industry 5.0 revolutions, researchers, clinicians, and regenerative medicine experts are exploring the plausibility of regenerating diseased or degenerated tissues to regain their near-normal biomechanical properties. In the past three decades, research on "Tissue Engineering and Regenerative Medicine" (TERM) has attained various milestones in clinical translation from bench to bedside. The regulatory bodies of various countries and states are working on the ethical use and guidelines for the production and storage of various cellular and acellular products. Platelets and platelet-derived by-products play a significant role in TERM. The growth factors and cytokines present in platelets regenerate the tissue of interest. In this connotation, a newer orthobiologic called "GOLD-induced cytokine" (GOLDIC) has become a product of interest among various regenerative medicine experts and researchers around the globe. Due to its potent anti-inflammatory action and potential systemic side effects, gold has been withdrawn from the management panel for rheumatoid arthritis. With the knowledge of its anti-inflammatory properties, researchers explored the utility of gold for tissue regeneration.
由于工业4.0和工业5.0革命，研究人员、临床医生和再生医学专家正在探索再生患病或退化组织以恢复其接近正常生物力学特性的可行性。在过去三十年中，“组织工程与再生医学”（TERM）研究在从实验室到临床的转化过程中取得了诸多里程碑式进展。各国及各州的监管机构正在制定各种细胞和无细胞产品生产与储存的伦理使用规范和指导方针。血小板及其衍生副产品在组织工程与再生医学中发挥着重要作用。血小板中存在的生长因子和细胞因子可使目标组织再生。在此背景下，一种名为“金诱导细胞因子”（GOLDIC）的新型再生生物制品已成为全球各地再生医学专家和研究人员关注的产品。由于金具有强大的抗炎作用及潜在的全身副作用，它已被从类风湿关节炎治疗方案中剔除。基于对其抗炎特性的了解，研究人员探索了金在组织再生方面的用途。
