Mason Thuy, Ní Dheasmhúnaigh Éirne, Ghazal Heba
School of Life Sciences, Pharmacy and Chemistry, Kingston University London, London, UK.
J Pharm Policy Pract. 2024 Dec 4;17(1):2432460. doi: 10.1080/20523211.2024.2432460. eCollection 2024.
Pharmacogenomics (PG), the study of how genetic variations impact individual responses to drugs, has seen significant advancements globally in recent years. Hospital pharmacists play a crucial role in multi-disciplinary teams and understanding their preparedness to deliver PG services is essential for successful integration into the healthcare systems. This study evaluates their knowledge, training and seeks their views on PG testing implementation.
A cross-sectional study was conducted on hospital pharmacists practising in Southwest London with the sample size determined as 137. The study was ethically approved. A structured, self-administered questionnaire was initially piloted, then distributed using emails with a link to Microsoft Form over a three-month period. It comprised 31 questions covering training levels, confidence, knowledge, perceptions, barriers to implementation and demographics.
A total of 46 responses were received achieving a response rate of 33.6%. The study revealed that 65% of participants had limited familiarity or understanding of PG. Over 50% indicated not receiving previous undergraduate or postgraduate training relevant to PG and accordingly their responses to the PG knowledge questions were lacking. Pharmacists with postgraduate training demonstrated better awareness and knowledge. An overwhelming number of participants envisaged carving a role for themselves favouring those that would complement their expertise in medicine management such as recommending appropriate treatment and dosages and suggestions based on PG testing results. Barriers identified were mostly concerning financial cost and shortage of trained staff to support PG services.
Most surveyed pharmacists were not prepared to deliver PG services and thus require tailored training; nonetheless, they exhibited a positive attitude towards PG suggesting a willingness to bridge learning gaps. This presents an opportunity for relevant organisations to provide necessary training and for universities to enhance the curriculum enabling pharmacists to be involved in PG implementation.
药物基因组学（PG）研究基因变异如何影响个体对药物的反应，近年来在全球取得了重大进展。医院药剂师在多学科团队中发挥着关键作用，了解他们提供PG服务的准备情况对于成功融入医疗保健系统至关重要。本研究评估他们的知识、培训情况，并征求他们对PG检测实施的看法。
对伦敦西南部执业的医院药剂师进行了一项横断面研究，样本量确定为137。该研究获得了伦理批准。最初对一份结构化的自填问卷进行了试点，然后在三个月的时间内通过电子邮件发送带有微软表单链接的问卷。问卷包含31个问题，涵盖培训水平、信心、知识、认知、实施障碍和人口统计学信息。
共收到46份回复，回复率为33.6%。研究表明，65%的参与者对PG的熟悉程度或了解有限。超过50%的人表示未接受过与PG相关的本科或研究生培训，因此他们对PG知识问题的回答缺乏。接受过研究生培训的药剂师表现出更好的意识和知识。绝大多数参与者设想为自己塑造一个角色，倾向于那些能补充他们药物管理专业知识的角色，比如根据PG检测结果推荐合适的治疗方法和剂量并提出建议。确定的障碍主要涉及财务成本和支持PG服务的训练有素的工作人员短缺。
大多数接受调查的药剂师没有准备好提供PG服务，因此需要量身定制培训；尽管如此，他们对PG表现出积极态度，表明愿意弥补知识差距。这为相关组织提供必要培训以及大学加强课程设置以使药剂师能够参与PG实施提供了机会。
