Vegt Donna E, Popa-Diaconu Delia A, Mulder Michelle L M, van Leuven Sander I, van der Horst-Bruinsma Irene E
Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Curr Rheumatol Rep. 2024 Dec 6;27(1):6. doi: 10.1007/s11926-024-01169-2.
This narrative review aims to discuss the most recent studies regarding the risk of cardiovascular disease (CVD) in women with psoriasis, psoriatic arthritis (PsA) and spondyloarthritis (SpA). In addition, the potential of menopause to modulate/increase CVD risk in women with these diseases will also be explored. It is of major interest to gain more understanding into this topic because it can have meaningful implications for screening and treatment of CVD risk in these women.
Literature shows that psoriasis, PsA, SpA and menopause itself cause higher CVD risks and higher CVD prevalence. This is predominantly explained by the increase of chronic systemic inflammation. No existing literature conclusively demonstrates or studies specifically whether the menopause amplifies this effect caused by psoriasis, PsA, or SpA.
Differences in pathophysiology of psoriasis, SpA and PsA versus the menopausal transition could suggest that menopause may increase the risk of CVD. However, the hypothesis that menopause represents an additional CV risk factor in women with psoriasis, PsA and SpA still needs to be thoroughly investigated and more clinical studies are required for further understanding and conclusions.
本叙述性综述旨在讨论关于银屑病、银屑病关节炎（PsA）和脊柱关节炎（SpA）女性患者心血管疾病（CVD）风险的最新研究。此外，还将探讨绝经在调节/增加这些疾病女性患者CVD风险方面的可能性。深入了解这一主题具有重要意义，因为它可能对这些女性的CVD风险筛查和治疗产生重要影响。
文献表明，银屑病、PsA、SpA以及绝经本身都会导致更高的CVD风险和更高的CVD患病率。这主要是由慢性全身炎症增加所致。目前尚无文献能够确凿证明或专门研究绝经是否会放大银屑病、PsA或SpA所导致的这种影响。
银屑病、SpA和PsA与绝经过渡在病理生理学上的差异可能表明绝经可能会增加CVD风险。然而，绝经是银屑病、PsA和SpA女性患者额外的心血管风险因素这一假设仍需深入研究，还需要更多临床研究以进一步理解并得出结论。
