银屑病和银屑病关节炎患者心肌梗死风险：一项全国性队列研究
Risk of Myocardial Infarction in Patients with Psoriasis and Psoriatic Arthritis: A Nationwide Cohort Study.
作者信息
Egeberg Alexander, Thyssen Jacob P, Jensen Peter, Gislason Gunnar H, Skov Lone
机构信息
Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark.
出版信息
Acta Derm Venereol. 2017 Jul 6;97(7):819-824. doi: 10.2340/00015555-2657.
Psoriasis has been associated with increased risk of myocardial infarction (MI) in some, but not all, studies. This study investigated the risk of MI in patients with psoriasis and psoriatic arthritis in Denmark. All residents aged ≥18 years from 1 January 2008 through 31 December 2012 were included. Adjusted hazard ratios (HRs) did not show an increased risk of MI in patients with mild psoriasis (HR 1.02; 95% confidence interval (95% CI) 0.96-1.09), whereas the risk was slightly increased in patients with severe psoriasis (HR 1.21; 1.07-1.37). Stratified by age, there was no increased risk of MI in any specific age group, regardless of severity. Limited to first-time MI, the risk was increased only in patients with severe psoriasis aged <50 years (HR 1.52; 1.03-2.25). The same applied to patients without psoriatic arthritis (severe psoriasis aged <50 years; HR 1.74; 1.11-2.72). In analyses restricted to patients with psoriatic arthritis, age-specific strata did not show any association between psoriatic arthritis and MI risk.
在一些但并非所有研究中，银屑病与心肌梗死（MI）风险增加相关。本研究调查了丹麦银屑病和银屑病关节炎患者发生MI的风险。纳入了2008年1月1日至2012年12月31日期间所有年龄≥18岁的居民。校正后的风险比（HRs）显示，轻度银屑病患者发生MI的风险未增加（HR 1.02；95%置信区间（95%CI）0.96 - 1.09），而重度银屑病患者的风险略有增加（HR 1.21；1.07 - 1.37）。按年龄分层，无论病情严重程度如何，任何特定年龄组发生MI的风险均未增加。仅限于首次发生MI的情况，仅在年龄<50岁的重度银屑病患者中风险增加（HR 1.52；1.03 - 2.25）。这同样适用于无银屑病关节炎的患者（年龄<50岁的重度银屑病患者；HR 1.74；1.11 - 2.72）。在仅限于银屑病关节炎患者的分析中，按年龄分层未显示银屑病关节炎与MI风险之间存在任何关联。
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