Carvalho Isabella Fernandes, Veloso Brenda Santos, da Cunha Filho José Ferreira, da Silva Cavalcante Samara Kelly, Ferreira Milena Regia Sousa, de Souza Maysa Luna, Bueno Daniela Franco
Centro Universitário Christus - UNICHRISTUS, Rua João Adolfo Gurgel, 133, Cocó, Fortaleza, Ceará, ZC-60190-180, Brazil.
Hospital Infantil Albert Sabin, Fortaleza, Ceará, Brazil.
Stem Cell Rev Rep. 2025 Feb;21(2):593-595. doi: 10.1007/s12015-024-10832-1. Epub 2024 Dec 6.
The use of tissue bioengineering strategies in dentistry has gained relevance. Many studies indicate that stem cells associated with biomaterials can regenerate intraoral tissues and have been applied to patients with cleft lip and palate (CLP). One of the treatments is alveolar bone reconstruction through bone grafts, where the bone is removed from the donor site and placed in the alveolar cleft. The use of stem cells from deciduous dental pulp, associated with a hydroxyapatite and collagen scaffold, can eliminate the need for autologous bone grafts, reducing pain and morbidity at the donor site. This study presents a case report in which a patient with cleft lip and palate was treated using this technique, resulting in complete filling of the alveolar cleft after 12 months.
组织生物工程策略在牙科领域的应用已变得愈发重要。许多研究表明，与生物材料相关的干细胞能够再生口腔内组织，并已应用于唇腭裂（CLP）患者。其中一种治疗方法是通过骨移植进行牙槽骨重建，即将骨从供体部位取出并放置在牙槽裂处。使用来自乳牙牙髓的干细胞，与羟基磷灰石和胶原蛋白支架相结合，可以消除对自体骨移植的需求，减少供体部位的疼痛和发病率。本研究呈现了一例唇腭裂患者使用该技术进行治疗的病例报告，结果在12个月后牙槽裂完全填充。
