Tsuchiya Masahiro, Tsuchiya Shinobu, Momma Haruki, Nagatomi Ryoichi, Yaegashi Nobuo, Arima Takahiro, Ota Chiharu, Igarashi Kaoru
Department of Nursing, Tohoku Fukushi University, Sendai, Miyagi, Japan.
Division of Craniofacial Anomalies, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, Japan.
PLoS One. 2024 Dec 6;19(12):e0313024. doi: 10.1371/journal.pone.0313024. eCollection 2024.
Bruxism, the involuntary activity of masticatory muscles, is common among individuals with autism spectrum disorders (ASD). Although bruxism is bidirectionally associated with sleep issues, whether an infant's sleep duration contributes to the development of bruxism remains unknown. In this study, a dataset (n = 83,720) obtained from the Japan Environment and Children's Study, a nationwide birth cohort study, was subjected to multiple imputations using logistic regression analysis with adjustments for several maternal and child-related variables. The aim of this study was to assess whether shorter sleep duration in the neonatal period additively affected the high prevalence of parent-reported bruxism (PRB) among children with ASD. The prevalences of ASD and PRB in the participants were 1.2% and 7.2%, respectively, and the odds ratio of the increased risk of PRB prevalence in individuals with ASD (95% confidence interval) was 1.59 (1.31-1.94) after covariate adjustments. Importantly, shorter sleep duration in the neonatal period (at one month of age) was significantly associated with an increased risk of PRB prevalence in individuals with ASD. The increased occurrence of bruxism, known to be highly prevalent among children with ASD, is associated with shorter sleep duration, particularly in the neonatal stage. Based on our results, a better understanding of the development of bruxism in individuals with ASD would provide valuable information for the prevention of oral diseases.
磨牙症是咀嚼肌的非自主活动，在自闭症谱系障碍（ASD）患者中很常见。尽管磨牙症与睡眠问题存在双向关联，但婴儿的睡眠时间是否会导致磨牙症的发生仍不清楚。在本研究中，我们使用逻辑回归分析对从日本环境与儿童研究（一项全国性的出生队列研究）中获得的数据集（n = 83,720）进行了多次插补，并对几个与母婴相关的变量进行了调整。本研究的目的是评估新生儿期较短的睡眠时间是否会增加自闭症谱系障碍儿童中家长报告的磨牙症（PRB）的高患病率。参与者中ASD和PRB的患病率分别为1.2%和7.2%，在进行协变量调整后，ASD患者中PRB患病率增加的风险比（95%置信区间）为1.59（1.31 - 1.94）。重要的是，新生儿期（1个月大时）较短的睡眠时间与ASD患者中PRB患病率增加的风险显著相关。已知在ASD儿童中高度普遍的磨牙症发生率增加与较短的睡眠时间有关，尤其是在新生儿期。基于我们的研究结果，更好地了解ASD患者磨牙症的发展将为预防口腔疾病提供有价值的信息。
