来自短果羊蹄甲（Bauhinia brychycarpa Wall. ex Benth.）的两种新的倍半萜醇咖啡酸酯及其α-葡萄糖苷酶抑制活性。
Two new sesquiterpenol caffeates from Bauhinia brychycarpa Wall. ex Benth. and their α-glucosidase inhibitory activity.
作者信息
Zhang Xingping, Ma Wenjie, Huang Kepu, Gao Congxi, Jiang Xiaoxue, Li Mingming, Wang Kou
机构信息
School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China.
Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, PR China.
出版信息
Fitoterapia. 2025 Jan;180:106327. doi: 10.1016/j.fitote.2024.106327. Epub 2024 Dec 4.
Two new sesquiterpenol caffeates, bausesquitate A (1) and bausesquitate B (2), were isolated from the stems and leaves of Bauhinia brychycarpa. Structures of two compounds were confirmed by UV, IR, HR-ESI-MS, 1D and 2D NMR, ECD spectra and DP4+ probability analysis. In vitro, compounds 1 and 2 showed better inhibitory effect on α-glucosidase than acarbose (IC = 280.50 ± 6.27 μM) with the IC values of 1.81 ± 0.12 μM and 3.79 ± 0.27 μM. Additionally, molecular docking and molecular dynamics simulation were performed to analyze the potential binding sites.
从短果羊蹄甲的茎和叶中分离出两种新的倍半萜烯醇咖啡酸酯，即短果倍半萜烯醇咖啡酸酯A（1）和短果倍半萜烯醇咖啡酸酯B（2）。通过紫外光谱、红外光谱、高分辨电喷雾电离质谱、一维和二维核磁共振谱、电子圆二色光谱和DP4 +概率分析确定了这两种化合物的结构。在体外，化合物1和2对α-葡萄糖苷酶的抑制作用比阿卡波糖（IC = 280.50±6.27μM）更好，其IC值分别为1.81±0.12μM和3.79±0.27μM。此外，还进行了分子对接和分子动力学模拟以分析潜在的结合位点。
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