来自沉香的新型三环[prezizaane]倍半萜。
New tricyclic prezizaane sesquiterpenoids from agarwood.
机构信息
Dali University Pharmacy and Chemistry College, Dali 671000, China.
Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
出版信息
Fitoterapia. 2019 Oct;138:104301. doi: 10.1016/j.fitote.2019.104301. Epub 2019 Aug 12.
Ten new tricyclic prezizaane types sesquiterpenoids (1-10) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp. Their structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new prezizaenes 1, 2 and 4 was determined by single-crystal X-ray diffraction, while TDDFT-ECD method was applied for 6. Compounds 4 and 5 displayed significant inhibitory activities toward α-glucosidase with IC values of 0.22 and 1.99 mM, respectively.
从沉香属植物来源的乙醚提取物中分离得到了 10 种新型三环 prezizaane 型倍半萜（1-10）。基于 1D 和 2D NMR 光谱以及 HRESIMS 数据，明确了它们的结构。通过单晶 X 射线衍射确定了新 prezizaenes 1、2 和 4 的绝对构型，而 TDDFT-ECD 方法则用于 6。化合物 4 和 5 对 α-葡萄糖苷酶表现出显著的抑制活性，IC 值分别为 0.22 和 1.99 mM。
Zotero 插件