Müller P, Dammann H G, Simon B
Arzneimittelforschung. 1986 Feb;36(2):269-70.
The effect of a 5- and 10-day treatment with indometacin and acemetacin (Rantudil) on the gastroduodenal mucosa was endoscopically evaluated in 16 healthy volunteers. In a randomised double-blind cross-over fashion the volunteers received 50 mg t.i.d. indometacin as well as 60 mg t.i.d. acemetacin. Acemetacin evoked after 5 and 10 days significantly less gastroduodenal lesions than indometacin. Possible reasons for this apparently better tolerability of acemetacin in man are discussed.
在16名健康志愿者中，通过内镜评估了消炎痛和阿西美辛（兰特锭）进行5天和10天治疗对胃十二指肠黏膜的影响。志愿者以随机双盲交叉方式接受每日3次、每次50mg的消炎痛以及每日3次、每次60mg的阿西美辛。5天和10天后，阿西美辛引起的胃十二指肠损伤明显少于消炎痛。文中讨论了阿西美辛在人体中耐受性明显更好的可能原因。
