人类动脉粥样硬化斑块中泡沫细胞的单核细胞起源。
Monocytic origin of foam cells in human atherosclerotic plaques.
作者信息
Aqel N M, Ball R Y, Waldmann H, Mitchinson M J
出版信息
Atherosclerosis. 1984 Dec;53(3):265-71. doi: 10.1016/0021-9150(84)90127-8.
PMID:6397199
Abstract
Foam cells in 4 human atherosclerotic plaques reacted with 3 rat monoclonal antibodies directed against T.200 ('anti-leucocyte common' antibody), HLA-Class II molecules and macrophage cytoplasm, respectively. Smooth muscle cells did not react. The results support the view that foam cells are monocyte-derived macrophages.
摘要
4例人类动脉粥样硬化斑块中的泡沫细胞分别与3种大鼠单克隆抗体发生反应，这3种抗体分别针对T.200（“抗白细胞共同”抗体）、HLA - II类分子和巨噬细胞胞质。平滑肌细胞未发生反应。这些结果支持了泡沫细胞是单核细胞衍生的巨噬细胞这一观点。
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