Cardia Luigi, Calapai Fabrizio, Mondello Cristina, Quattrone Domenico, Elisa Sorbara Emanuela, Mannucci Carmen, Calapai Gioacchino, Mondello Epifanio
Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi Bonino-Pulejo.
Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina.
Medicine (Baltimore). 2020 Oct 16;99(42):e22253. doi: 10.1097/MD.0000000000022253.
Omega-3 fatty acids (FAs) can produce several beneficial effects and are commonly used for the treatment of migraine symptoms. Although current therapeutic measures for migraine included pharmacological therapies, dietary supplements, and herbal ingredients, dietary patterns, acupuncture, relaxation techniques, biofeedback, and psychotherapy, omega-3 FAs therapeutic role seems to be obtained through the inhibition or reduction of the release of inflammatory cytokines. The present review aims to provide updated information about the effects of omega-3 FAs in migraine treatment, investigating their clinical effects alone or in combination with other substances.
Bibliographic research was conducted by examining scientific literature from January 2000 until January 31, 2020. Ten clinical studies were included in the review. Quality assessment of randomized controlled trials was performed by using the JADAD scale.
Clinical studies methodology is not always of good quality and results show moderate evidence concerning the therapeutic role of omega-3 FAs in migraine.
Further clinical trials are necessary to implement the knowledge concerning the use of omega-3 fatty acids in the treatment of migraine.
ω-3脂肪酸（FAs）具有多种有益作用，常用于治疗偏头痛症状。尽管目前偏头痛的治疗措施包括药物治疗、膳食补充剂、草药成分、饮食模式、针灸、放松技巧、生物反馈和心理治疗，但ω-3脂肪酸的治疗作用似乎是通过抑制或减少炎症细胞因子的释放来实现的。本综述旨在提供有关ω-3脂肪酸在偏头痛治疗中作用的最新信息，研究其单独使用或与其他物质联合使用的临床效果。
通过查阅2000年1月至2020年1月31日的科学文献进行文献研究。本综述纳入了10项临床研究。采用JADAD量表对随机对照试验进行质量评估。
临床研究方法的质量并不总是很高，结果显示关于ω-3脂肪酸在偏头痛治疗中的作用仅有中等证据。
需要进一步的临床试验来完善有关使用ω-3脂肪酸治疗偏头痛的知识。
