Serfontein W J, Ubbink J B, De Villiers L S, Becker P J
Atherosclerosis. 1986 Mar;59(3):341-6. doi: 10.1016/0021-9150(86)90131-0.
Tobacco-smoking men (n = 106) showed considerably lower plasma pyridoxal-5'-phosphate levels (P less than 0.001) than non-smoking controls (n = 143). A previously reported inverse relationship between plasma pyridoxal-5'-phosphate levels and age is confirmed by using new and sensitive high-performance liquid chromatography methodology for pyridoxal-5'-phosphate determinations. Plasma pyridoxal levels were neither lower in tobacco-smoking men nor could any relationship between pyridoxal levels and age be demonstrated. Two major risk factors for coronary artery disease, tobacco-smoking and increasing age, are thus associated with lower plasma pyridoxal-5'-phosphate levels.
吸烟男性（n = 106）的血浆磷酸吡哆醛-5'-磷酸水平显著低于非吸烟对照组（n = 143）（P < 0.001）。通过使用用于测定磷酸吡哆醛-5'-磷酸的新型灵敏高效液相色谱方法，证实了先前报道的血浆磷酸吡哆醛-5'-磷酸水平与年龄之间的负相关关系。吸烟男性的血浆吡哆醛水平既不更低，也未显示出吡哆醛水平与年龄之间存在任何关系。因此，冠状动脉疾病的两个主要危险因素，即吸烟和年龄增长，都与较低的血浆磷酸吡哆醛-5'-磷酸水平相关。
