Delport R, Ubbink J B, Serfontein W J, Becker P J, Walters L
Department of Chemical Pathology, University of Pretoria, South Africa.
Int J Vitam Nutr Res. 1988;58(1):67-72.
Plasma pyridoxal-5'-phosphate concentrations were significantly lower (p less than 0.001) in a group of 28 asthmatic women when compared to 33 controls. Plasma pyridoxal levels in the two groups were not different. Theophylline was administered to a group of 17 volunteers and resulted in large reductions in plasma pyridoxal-5'-phosphate levels, while plasma pyridoxal levels and urinary 4-pyridoxic acid excretion were unaffected by theophylline therapy. An in vitro study showed that theophylline did not interfere with the high performance liquid chromatography assay for pyridoxal-5'-phosphate, indicating that theophylline could affect liver metabolism of vitamin B6.
与33名对照者相比，一组28名哮喘女性的血浆磷酸吡哆醛-5'-磷酸浓度显著降低（p<0.001）。两组的血浆吡哆醛水平没有差异。对一组17名志愿者给予茶碱治疗，结果血浆磷酸吡哆醛-5'-磷酸水平大幅降低，而血浆吡哆醛水平和尿中4-吡哆酸排泄不受茶碱治疗的影响。一项体外研究表明，茶碱不干扰磷酸吡哆醛-5'-磷酸的高效液相色谱测定，这表明茶碱可能影响维生素B6的肝脏代谢。
