Kim Donghee, Kwon Hyun, Hwang Jiyi, Jung Ji Seung, Kwon Myeongjee, Yong Jungyeon, Yoon Haerin, Kim Soohyun, Park Kyung-Mee
Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
Comparative Ophthalmology, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, USA.
Vet Ophthalmol. 2024 Dec 6. doi: 10.1111/vop.13303.
This study aimed to explore anatomical differences in the aqueous humor (AH) outflow pathway between male and female dogs using ultrasound biomicroscopy (UBM).
Clinical data were collected from 30 eyes of 30 dogs (15 males: 10 right eyes, 5 left eyes; and 15 females: 7 right eyes, 8 left eyes) treated at the Veterinary Medical Teaching Hospital of Chungbuk National University, South Korea, between August 2018 and February 2024.
The study conducted an in-depth UBM examination, specifically observing peripheral anterior chamber depth (ACD), geometric iridocorneal angle (ICA), and angle-opening distance (AOD) alongside measurements of ciliary cleft width (CCW), length (CCL), and area (CCA), and assessed the longitudinal fibers of ciliary muscle thickness (Lf-CMT) and the longitudinal and radial fibers of ciliary muscle thickness (LRf-CMT) for gender-based differences.
The study identified a significant sex difference in peripheral ACD, with females displaying shallower depths compared to males, potentially clarifying the higher incidence of glaucoma in female dogs. No significant gender differences were found in ICA, AOD, CC parameters, or ciliary muscle parameters measurements.
This research uncovered that peripheral ACD is significantly shallower in females than in males, potentially indicating a risk factor that could contribute to the development of primary angle-closure glaucoma.
本研究旨在使用超声生物显微镜（UBM）探索雄性和雌性犬房水流出途径的解剖学差异。
收集了2018年8月至2024年2月期间在韩国忠北国立大学兽医学院教学医院接受治疗的30只犬（15只雄性：10只右眼，5只左眼；15只雌性：7只右眼，8只左眼）的30只眼睛的临床数据。
该研究进行了深入的UBM检查，具体观察周边前房深度（ACD）、几何虹膜角膜角（ICA）和房角开放距离（AOD），同时测量睫状裂宽度（CCW）、长度（CCL）和面积（CCA），并评估睫状肌厚度的纵向纤维（Lf-CMT）以及睫状肌厚度的纵向和径向纤维（LRf-CMT）的性别差异。
该研究发现周边ACD存在显著的性别差异，雌性的深度比雄性浅，这可能解释了雌性犬青光眼发病率较高的原因。在ICA、AOD、CC参数或睫状肌参数测量中未发现显著的性别差异。
本研究发现雌性的周边ACD明显比雄性浅，这可能表明这是一个可能导致原发性闭角型青光眼发生的危险因素。
