Mohammed Ahmed, Mahon Eimear, Moore Niamh, Sweetman Lorna, Maher Michael, O'Regan Patrick, England Andrew, McEntee Mark F
Discipline of Medical Imaging and Radiation Therapy, School of Medicine, University College Cork, Cork, Ireland.
Radiological Sciences Department, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
Eur J Pediatr. 2024 Dec 7;184(1):69. doi: 10.1007/s00431-024-05894-9.
The diagnosis of suspected physical abuse (SPA) remains a continuous challenge to paediatric healthcare. Several studies have reported that computed tomography (CT) improves the evaluation of SPA. This study aims to systematically review the diagnostic performance of CT compared to radiography in investigating skull and chest fractures for SPA. Multiple databases were searched, using PRISMA methods, from 2008 to August 2024 for relevant studies in English. Two reviewers independently screened and selected relevant studies using Covidence software. The QUADAS-2 tool was used for the quality assessment of the included papers. Sensitivity, specificity and the effective radiation dose of CT and radiography from the included studies were extracted. Pooled sensitivity and specificity were calculated with their respective 95% confidence intervals (CI). GRADE criteria were used to appraise the overall quality of the synthesis. Of the 4057 identified papers, 10 met the inclusion criteria; all 10 included skull and/or chest. The overall sensitivity and specificity of CT were 96.5% (95% CI, 94.9-97.7%) and 99.5% (95% CI, 99.1-99.8%), respectively. Compared to the sensitivity and specificity of radiography, 59.8% (95% CI, 56.2-63.3%) and 99.7% (95% CI, 99.3-99.8%), respectively. Conclusion: CT sensitivity is significantly higher than radiography in detecting rib and skull fractures for SPA. The effective dose for chest LDCT is comparable to that of radiography. Therefore, LDCT should be considered a potential replacement to radiography in SPA investigations for the chest and skull. What is Known • CT shows higher diagnostic performance than radiography in detecting skull and rib fractures in the diagnosis of SPA. What is New • When a head CT scan is acquired for SPA diagnosis at any age, the two-view skull radiograph can be safely eliminated from the Skeletal Survey protocol, likewise, Chest CT can replace chest radiography for SPA diagnosis of rib fractures. • The effective dose and image quality of low-dose chest CT is comparable to that of two-view chest radiography for SPA diagnosis.
疑似身体虐待(SPA)的诊断仍然是儿科医疗保健面临的持续挑战。多项研究报告称,计算机断层扫描(CT)可改善对SPA的评估。本研究旨在系统评价CT与X线摄影在调查SPA的颅骨和肋骨骨折方面的诊断性能。采用PRISMA方法,检索了2008年至2024年8月的多个数据库,以查找英文相关研究。两名评审员使用Covidence软件独立筛选和选择相关研究。采用QUADAS - 2工具对纳入论文进行质量评估。提取纳入研究中CT和X线摄影的敏感性、特异性及有效辐射剂量。计算合并敏感性和特异性及其各自的95%置信区间(CI)。采用GRADE标准评估综合分析的整体质量。在4057篇已识别的论文中,10篇符合纳入标准;所有10篇均包括颅骨和/或胸部。CT的总体敏感性和特异性分别为96.5%(95%CI,94.9 - 97.7%)和99.5%(95%CI,99.1 - 99.8%)。与X线摄影的敏感性和特异性相比,分别为59.8%(95%CI,56.2 - 63.3%)和99.7%(95%CI,99.3 - 99.8%)。结论:在检测SPA的肋骨和颅骨骨折方面,CT的敏感性显著高于X线摄影。胸部低剂量CT(LDCT)的有效剂量与X线摄影相当。因此,在SPA的胸部和颅骨检查中,LDCT应被视为X线摄影的潜在替代方法。已知信息:在SPA诊断中,CT在检测颅骨和肋骨骨折方面显示出比X线摄影更高的诊断性能。新发现:在任何年龄进行头部CT扫描以诊断SPA时,骨骼检查方案中可以安全地省略双视图颅骨X线摄影,同样,胸部CT可以替代胸部X线摄影用于SPA的肋骨骨折诊断。• 低剂量胸部CT的有效剂量和图像质量与双视图胸部X线摄影用于SPA诊断时相当。