de Souza Thales Batista, Máximo Roberta de Oliveira, Cruz E Souza Isabella Letícia de Pádua, da Silva Thaís Barros Pereira, Luiz Mariane Marques, Lima Sara Souza, Cochar-Soares Natália, Silveira Leticia Coelho, Guandalini Valdete Regina, Tofani Patrícia Silva, Steptoe Andrew, de Oliveira Cesar, Alexandre Tiago da Silva
Postgraduate programme in Gerontology, Federal University of Sao Carlos, Rodovia Washington Luís, km 235, SP-310, Sao Carlos, São Paulo, Brazil.
Postgraduate programme in Physical Therapy, Federal University of Sao Carlos, Rodovia Washington Luís, km 235, SP-310, Sao Carlos, São Paulo, Brazil.
Arch Gerontol Geriatr. 2025 Mar;130:105701. doi: 10.1016/j.archger.2024.105701. Epub 2024 Nov 22.
This study aims to evaluate whether obstructive or restrictive lung disorders are associated with the incidence of dynapenia in individuals aged 50 and over.
Longitudinal study involving 4,975 participants from the English Longitudinal Study of Aging (ELSA) aged 50 or older, without dynapenia at baseline, followed for eight years. Lung function was assessed by spirometry (predicted percentage) and participants were classified as no pulmonary disorder (FEV ≥ 80 %, FVC ≥ 80 % and FEV/FVC ≥ 70 %); with obstructive pulmonary disorder (FEV < 80 %, FEV/FVC < 70 % and normal FVC or < 80 %); or with restrictive pulmonary disorder (FVC < 80 %, FEV/FVC > 70 % and normal or < 80 % FEV). The incidence of dynapenia was defined by handgrip strength < 26 kg for men and < 16 kg for women. Association between obstructive or restrictive pulmonary disorders and the incidence of dynapenia were investigated using Poisson regression models adjusted for sociodemographic, behavioural, and clinical characteristics.
The incidence density of dynapenia was 14.2/1000 person-years (95 %CI 12.6-15.9) in those without pulmonary disorders, 25.1/1000 person-years (95 % CI 21.2-29.7) in those with restrictive pulmonary disorders and 36.6/1000 person-years (95 % CI 23.8-56.1) in those with obstructive pulmonary disorders. Having an obstructive pulmonary disorder increased the risk of developing dynapenia by 62 % (95 % CI 1.09-2.41), while having a restrictive pulmonary disorder increased the risk by 37 % (95 % CI 1.13-1.64).
Obstructive and restrictive pulmonary disorders are risk factors for a higher incidence of dynapenia in individuals aged 50 years or older.
本研究旨在评估阻塞性或限制性肺部疾病是否与50岁及以上人群的肌无力发生率相关。
纵向研究纳入了4975名来自英国老龄化纵向研究（ELSA）的50岁及以上参与者，这些参与者在基线时无肌无力，随访8年。通过肺活量测定法（预测百分比）评估肺功能，参与者被分类为无肺部疾病（FEV≥80%，FVC≥80%且FEV/FVC≥70%）；患有阻塞性肺部疾病（FEV<80%，FEV/FVC<70%且FVC正常或<80%）；或患有限制性肺部疾病（FVC<80%，FEV/FVC>70%且FEV正常或<80%）。肌无力的发生率定义为男性握力<26kg，女性握力<16kg。使用经社会人口统计学、行为和临床特征调整的泊松回归模型研究阻塞性或限制性肺部疾病与肌无力发生率之间的关联。
无肺部疾病者的肌无力发病密度为14.2/1000人年（95%CI 12.6 - 15.9），患有限制性肺部疾病者为25.1/1000人年（95%CI 21.2 - 29.7），患有阻塞性肺部疾病者为36.6/1000人年（95%CI 23.8 - 56.1）。患有阻塞性肺部疾病会使发生肌无力的风险增加62%（95%CI 1.09 - 2.41），而患有限制性肺部疾病会使风险增加37%（95%CI 1.13 - 1.64）。
阻塞性和限制性肺部疾病是50岁及以上人群中肌无力发生率较高的危险因素。
