Liu Houli, Ouyang Zhaorong, Li Siyu
School of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui Province 230012, China.
School of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui Province 230012, China.
Biomed Pharmacother. 2024 Dec;181:117735. doi: 10.1016/j.biopha.2024.117735. Epub 2024 Dec 6.
Extracellular vesicles derived from classically activated M1 macrophages (M1 EVs) have shown great potential in both tumor treatment and drug delivery. M1 EVs inherit specific biological messengers from their parent cells and possess the capability to activate immune cells residing in close or distant tumor tissues for antitumor therapy. Moreover, M1 EVs are commonly used as an attractive drug delivery system due to their tumor-targeting ability, biocompatibility, and non-toxic. They can effectively encapsulate various therapeutic cargoes through specific methods such as electroporation, co-incubation, sonication, extrusion, transfection, or click chemistry reaction. In this review, we provide a comprehensive summary of the advancements in M1 EVs for tumor therapy, discussing their application prospects and existing problems.
源自经典活化的M1巨噬细胞的细胞外囊泡（M1 EVs）在肿瘤治疗和药物递送方面都显示出了巨大潜力。M1 EVs从其母细胞继承特定的生物信使，并具有激活位于近处或远处肿瘤组织中的免疫细胞以进行抗肿瘤治疗的能力。此外，M1 EVs由于其肿瘤靶向能力、生物相容性和无毒特性，通常被用作一种有吸引力的药物递送系统。它们可以通过电穿孔、共孵育、超声处理、挤压、转染或点击化学反应等特定方法有效地封装各种治疗性货物。在这篇综述中，我们全面总结了M1 EVs在肿瘤治疗方面的进展，讨论了它们的应用前景和存在的问题。
