Prefrontal tDCS fails to modulate memory retrieval in younger and older adults.

Previous research shows that a single session of anodal transcranial direct current stimulation (tDCS) to the left dorsolateral prefrontal cortex (dlPFC) can improve the accuracy of episodic memory retrieval, but stimulation effects are not always found and may be moderated by time of day. Here, we report the results from a rigorous clinical trial (NCT03723850) designed to replicate these tDCS findings in younger adults and extend them to cognitively normal older adults. We conducted the largest double-blind, between-subjects tDCS study on memory retrieval in younger and older adults to date. 150 younger adults and 91 older adults received anodal tDCS or sham stimulation to the left dlPFC prior to episodic memory retrieval and working memory tasks. We also manipulated when tDCS was administered (time of day: morning vs. afternoon), task difficulty (easy vs. hard), and stimulus format (verbal vs. visual/pictorial) to test the extent that these variables are important for identifying tDCS effects. Contrary to our preregistered predictions, we did not find any effect of tDCS or time of day on younger or older adults' episodic or working memory performance. This outcome was not due to insensitivity of our cognitive tasks, given that we found expected effects of task difficulty and age-related effects on our memory measures. Based on these and prior tDCS results, we conclude that a single dose of tDCS using the typical and often recommended parameters does not reliably improve episodic memory retrieval in either age group.