de Lara Gabriel A, Knechtges Philipp N, Paulus Walter, Antal Andrea
Department of Clinical Neurophysiology, University Medical Center Goettingen, Georg-August University of GoettingenGöttingen, Germany.
Front Neurosci. 2017 Aug 8;11:452. doi: 10.3389/fnins.2017.00452. eCollection 2017.
Several studies imply that anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) can modulate the formation of verbal episodic memories. The aim of this study was to test if tDCS through a multi-electrode Laplacian montage over the left DLPFC could differentially modulate declarative memory performance depending on the application phase. Two groups of healthy participants ( = 2 × 15) received 1 mA anodal or sham stimulation for 20 min during the encoding or during the recall phase on a delayed cued-recall, using a randomized, double-blinded, repeated-measures experimental design. Memory performance was assessed at two time points: 10 min and 24 h after learning. We found no significant difference between anodal and sham stimulation with regard to the memory scores between conditions (stimulation during encoding or recall) or between time points, suggesting that anodal tDCS over the left DLPFC with these stimulation parameters had no effect on the encoding and the consolidation of associative verbal content.
多项研究表明，经颅直流电刺激（tDCS）作用于左侧背外侧前额叶皮层（DLPFC）可调节言语情景记忆的形成。本研究旨在测试，通过多电极拉普拉斯蒙太奇技术作用于左侧DLPFC的tDCS是否会根据应用阶段不同而对陈述性记忆表现产生不同的调节作用。两组健康参与者（每组15人）在延迟线索回忆任务的编码阶段或回忆阶段接受1毫安的阳极刺激或伪刺激，持续20分钟，采用随机、双盲、重复测量实验设计。在学习后的两个时间点（10分钟和24小时）评估记忆表现。我们发现，在不同条件下（编码或回忆阶段的刺激）或不同时间点之间，阳极刺激和伪刺激在记忆分数方面没有显著差异，这表明采用这些刺激参数的左侧DLPFC阳极tDCS对联想言语内容的编码和巩固没有影响。
