Bowyer J J, Busst C M, Denison D M, Shinebourne E A
Br Heart J. 1986 Apr;55(4):385-90. doi: 10.1136/hrt.55.4.385.
Inhalation of 100% oxygen by nine children with pulmonary vascular disease increased pulmonary blood flow measured at cardiac catheterisation; there was no significant change in pulmonary artery pressure. Fifteen children with pulmonary vascular disease that was severe enough to preclude corrective cardiac operation were studied to determine the effect of long term oxygen treatment on pulmonary vascular disease. Nine received long term domiciliary oxygen for a minimum of twelve hours a day for up to five years. Though the untreated group closely resembled the treated group their survival was significantly less good. All nine treated children are alive whereas five of the six children who did not receive oxygen have died.
9名患有肺血管疾病的儿童吸入100%氧气后，心导管检查测得的肺血流量增加；肺动脉压力无显著变化。对15名患有严重到无法进行心脏矫正手术的肺血管疾病儿童进行了研究，以确定长期吸氧治疗对肺血管疾病的影响。9名儿童每天在家吸氧至少12小时，持续长达5年。虽然未治疗组与治疗组非常相似，但未治疗组的存活率明显较低。所有9名接受治疗的儿童都还活着，而6名未吸氧儿童中有5名已经死亡。
