随机试验：当科学严谨性遇上实地现实。

Randomized trials: When scientific rigor meets field reality.

作者信息

Hannoun-Levi J M, Savignoni A, Lemonnier J, Kirova Youlia

机构信息

Department of Radiation Oncology, Antoine Lacassagne Cancer Centre, University Cote d'Azur, Nice, France.

Department of Bio Statistics, Institute Curie, Paris, France.

出版信息

Radiother Oncol. 2025 Feb;203:110659. doi: 10.1016/j.radonc.2024.110659. Epub 2024 Dec 5.

DOI:10.1016/j.radonc.2024.110659

PMID:39645200

Abstract

Results from prospective randomized trial results are required to provide practice-changing level-1 evidence. However, if such a trial is not feasible, we should not accept that consequently practice could not change. We discuss hereby a pragmatically approach based on methodological alternatives.

摘要

前瞻性随机试验结果是提供能改变临床实践的一级证据所必需的。然而，如果这样的试验不可行，我们不应因此就认为临床实践无法改变。在此，我们讨论一种基于方法学替代方案的实用方法。