使用简单分光光度法对唾液和血清中扑热息痛水平的比较研究。
A comparative study of saliva and serum paracetamol levels using a simple spectrophotometric method.
作者信息
Adithan C, Thangam J
出版信息
Br J Clin Pharmacol. 1982 Jul;14(1):107-9. doi: 10.1111/j.1365-2125.1982.tb04944.x.
Abstract
The relationship between saliva and serum paracetamol levels was investigated in ten healthy male volunteers. The salivary and serum paracetamol levels showed significant correlation with each other. The salivary and serum paracetamol concentration ratio was highly dependent on sampling time. The salivary and serum paracetamol half-lives showed significant correlation with each other while the area under curve of paracetamol concentration in saliva and serum failed to show significant correlation.
摘要
在10名健康男性志愿者中研究了唾液和血清中对乙酰氨基酚水平之间的关系。唾液和血清中对乙酰氨基酚水平之间显示出显著相关性。唾液与血清中对乙酰氨基酚浓度比高度依赖于采样时间。唾液和血清中对乙酰氨基酚的半衰期之间显示出显著相关性，而唾液和血清中对乙酰氨基酚浓度曲线下面积未显示出显著相关性。
相似文献
1
A comparative study of saliva and serum paracetamol levels using a simple spectrophotometric method.使用简单分光光度法对唾液和血清中扑热息痛水平的比较研究。
Br J Clin Pharmacol. 1982 Jul;14(1):107-9. doi: 10.1111/j.1365-2125.1982.tb04944.x.
2
Salivary paracetamol elimination kinetics during the menstrual cycle.月经周期中唾液对乙酰氨基酚的消除动力学。
Br J Clin Pharmacol. 1987 Mar;23(3):348-50. doi: 10.1111/j.1365-2125.1987.tb03056.x.
3
Saliva vs. plasma bioequivalence of paracetamol in humans: validation of class I drugs of the salivary excretion classification system.
Drug Res (Stuttg). 2014 Oct;64(10):559-62. doi: 10.1055/s-0033-1363995. Epub 2014 Jan 22.
4
Effect of short surgical procedures on salivary paracetamol elimination.短期外科手术对唾液中扑热息痛消除的影响。
Br J Clin Pharmacol. 1985 Aug;20(2):174-6. doi: 10.1111/j.1365-2125.1985.tb05054.x.
5
Oral ciprofloxacin affects the pharmacokinetics of paracetamol in saliva.口服环丙沙星会影响唾液中对乙酰氨基酚的药代动力学。
Clin Drug Investig. 2006;26(4):223-6. doi: 10.2165/00044011-200626040-00007.
6
Salivary secretion of paracetamol in man.对乙酰氨基酚在人体中的唾液分泌情况。
J Pharm Pharmacol. 1987 Feb;39(2):150-2. doi: 10.1111/j.2042-7158.1987.tb06967.x.
7
The effect of chloroquine on paracetamol disposition and kinetics.氯喹对扑热息痛处置和动力学的影响。
Br J Clin Pharmacol. 1986 Mar;21(3):322-4. doi: 10.1111/j.1365-2125.1986.tb05197.x.
8
Effect of halothane anaesthesia on salivary elimination of paracetamol.
Eur J Clin Pharmacol. 1986;30(3):371-3. doi: 10.1007/BF00541548.
9
Salivary excretion of paracetamol in man.
J Pharm Pharmacol. 1973 May;25(5):420-1. doi: 10.1111/j.2042-7158.1973.tb10042.x.
10
Paracetamol (acetaminophen) clearance in patients with cirrhosis of the liver.肝硬化患者对乙酰氨基酚（扑热息痛）的清除率。
Acta Med Scand Suppl. 1979;624:99-105. doi: 10.1111/j.0954-6820.1979.tb00728.x.
引用本文的文献
1
Albendazole metabolites excretion in human saliva as a biomarker to assess treatment compliance in mass drug administration (MDA) anthelmintic programs.阿苯达唑代谢物在人唾液中的排泄可作为评估大规模药物驱虫治疗方案中治疗依从性的生物标志物。
Sci Rep. 2024 Mar 15;14(1):6271. doi: 10.1038/s41598-024-56804-w.
2
Saliva Versus Plasma Bioequivalence of Azithromycin in Humans: Validation of Class I Drugs of the Salivary Excretion Classification System.阿奇霉素在人体中的唾液与血浆生物等效性：唾液排泄分类系统中I类药物的验证
Drugs R D. 2017 Mar;17(1):219-224. doi: 10.1007/s40268-016-0170-8.
3
Bioavailability of paracetamol with/without caffeine in Egyptian patients with hepatitis C virus.对乙酰氨基酚在有/无咖啡因情况下对埃及丙型肝炎病毒患者的生物利用度。
Eur J Clin Pharmacol. 2016 May;72(5):573-82. doi: 10.1007/s00228-016-2025-1. Epub 2016 Feb 18.
4
Correlation of paired toxic plasma and saliva paracetamol concentrations following deliberate self-poisoning with paracetamol.有意服用扑热息痛后配对的中毒血浆和唾液扑热息痛浓度的相关性。
Br J Clin Pharmacol. 2012 Jul;74(1):154-60. doi: 10.1111/j.1365-2125.2011.04157.x.
5
UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables.UGT1A6 和 UGT2B15 多态性与乙酰氨基酚结合反应对随机对照选择水果和蔬菜饮食的影响。
Drug Metab Dispos. 2011 Sep;39(9):1650-7. doi: 10.1124/dmd.111.039149. Epub 2011 Jun 10.
6
Is one paracetamol suppository of 1000 mg bioequivalent with two suppositories of 500 mg.一粒1000毫克的对乙酰氨基酚栓剂与两粒500毫克的栓剂生物等效吗？
Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):203-6. doi: 10.1007/BF03189340.
7
Estimation of agitation intensity in the GI tract in humans and dogs based on in vitro/in vivo correlation.基于体外/体内相关性对人和犬胃肠道内搅拌强度的评估。
Pharm Res. 1995 Feb;12(2):237-43. doi: 10.1023/a:1016231010301.
8
Oral solid controlled release dosage forms: role of GI-mechanical destructive forces and colonic release in drug absorption under fasted and fed conditions in humans.口服固体控释剂型：胃肠道机械破坏力及结肠释放在人体禁食和进食条件下药物吸收中的作用
Pharm Res. 1995 Jul;12(7):1049-54. doi: 10.1023/a:1016270701021.
9
Influence of sex and oral contraceptive steroids on paracetamol metabolism.性别及口服避孕药类固醇对扑热息痛代谢的影响。
Br J Clin Pharmacol. 1983 Nov;16(5):503-9. doi: 10.1111/j.1365-2125.1983.tb02207.x.
10
Effect of short surgical procedures on salivary paracetamol elimination.短期外科手术对唾液中扑热息痛消除的影响。
Br J Clin Pharmacol. 1985 Aug;20(2):174-6. doi: 10.1111/j.1365-2125.1985.tb05054.x.
本文引用的文献
1
Salivary excretion of paracetamol in man.
J Pharm Pharmacol. 1973 May;25(5):420-1. doi: 10.1111/j.2042-7158.1973.tb10042.x.
2
A rapid, simple acetaminophen spectrophotometric determination.一种快速、简便的对乙酰氨基酚分光光度测定法。
Pediatrics. 1979 Apr;63(4):609-11.
3
Therapeutic drug monitoring in saliva.唾液中的治疗药物监测。
Clin Pharmacokinet. 1978 Jan-Feb;3(1):39-57. doi: 10.2165/00003088-197803010-00003.
Zotero 插件