Nishioka Michele Akemi, Brassolatti Patricia, Alves Ana Carolina Araruna, Dorigatti Jéssica Helena Franco, Chieregato Fabiele, de Almeida Stephani, Farias Stephany Luanna Queiroga, Meyer Patricia Froes, de Souza José Ricardo
Department of Research, Development and Innovation at Brazilian Medical Equipment Industry (IBRAMED), Amparo, Brazil.
Federal University of Rio Grande do Norte (UFRN), Natal, Brazil.
J Cosmet Dermatol. 2025 Feb;24(2):e16675. doi: 10.1111/jocd.16675. Epub 2024 Dec 8.
Reverse the fat accumulation and to improve body contouring with more safely than invasive procedures has become a necessary therapeutic approach, but little detailed when using LED photobiomodulation.
To evaluate an application protocol with two different wavelengths (red and infrared LED) consecutively in the abdomen region alone or associated with the dermocosmetics application with lipolytic properties.
Ninety patients with a significant amount of adipose tissue in the abdomen region were selected and randomized into three groups: Sham (SG), in which patients received a simulation of the treatment; LED (LG), in which participants received the application with LED; LED with dermocosmetic (LDG), in which the participants underwent a combination of LED and dermocosmetic treatment. The following assessments were carried out: anthropometric data (weight, height, perimetry, and adipometry); ultrasound examination to adipose layer; patient satisfaction questionnaire; histology of a donated a tissue sample.
The main findings were a decrease in umbilical perimetry, a significant decrease in the body fat layer determined by ultrasound and significant histological changes that indicated an improvement in the appearance of the skin and an increase in the amount of macrophages in the subcutaneous layer. Histological data also showed an improvement in the appearance of the skin with an increase in collagen deposition and an increase in macrophages in the subcutaneous layer.
The LED phototherapy application protocol, both alone and in association with the dermocosmetic, with the emission of two consecutive wavelengths, was effective in reducing the fat tissue in the abdomen region.
与侵入性手术相比，更安全地逆转脂肪堆积并改善身体轮廓已成为一种必要的治疗方法，但在使用LED光生物调节时细节较少。
评估一种应用方案，该方案在腹部区域连续使用两种不同波长（红色和红外LED），单独使用或与具有脂肪分解特性的皮肤化妆品联合使用。
选择90例腹部区域有大量脂肪组织的患者，随机分为三组：假手术组（SG），患者接受模拟治疗；LED组（LG），参与者接受LED治疗；LED与皮肤化妆品联合组（LDG），参与者接受LED和皮肤化妆品联合治疗。进行了以下评估：人体测量数据（体重、身高、周长和脂肪测量）；脂肪层超声检查；患者满意度问卷；捐赠组织样本的组织学检查。
主要发现是脐周周长减小，超声测定的体脂层显著减小，以及显著的组织学变化，表明皮肤外观改善，皮下层巨噬细胞数量增加。组织学数据还显示皮肤外观改善，胶原蛋白沉积增加，皮下层巨噬细胞增加。
单独或与皮肤化妆品联合使用的LED光疗应用方案，通过连续发射两种波长，对减少腹部区域的脂肪组织有效。
