Avci Pinar, Gupta Asheesh, Sadasivam Magesh, Vecchio Daniela, Pam Zeev, Pam Nadav, Hamblin Michael R
Department of Dermatology, Harvard Medical School, BAR 414 Wellman, Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA.
Semin Cutan Med Surg. 2013 Mar;32(1):41-52.
Low-level laser (light) therapy (LLLT) is a fast-growing technology used to treat a multitude of conditions that require stimulation of healing, relief of pain and inflammation, and restoration of function. Although skin is naturally exposed to light more than any other organ, it still responds well to red and near-infrared wavelengths. The photons are absorbed by mitochondrial chromophores in skin cells. Consequently, electron transport, adenosine triphosphate nitric oxide release, blood flow, reactive oxygen species increase, and diverse signaling pathways are activated. Stem cells can be activated, allowing increased tissue repair and healing. In dermatology, LLLT has beneficial effects on wrinkles, acne scars, hypertrophic scars, and healing of burns. LLLT can reduce UV damage both as a treatment and as a prophylactic measure. In pigmentary disorders such as vitiligo, LLLT can increase pigmentation by stimulating melanocyte proliferation and reduce depigmentation by inhibiting autoimmunity. Inflammatory diseases such as psoriasis and acne can also be managed. The noninvasive nature and almost complete absence of side effects encourage further testing in dermatology.
低强度激光（光）疗法（LLLT）是一种快速发展的技术，用于治疗多种需要促进愈合、缓解疼痛和炎症以及恢复功能的病症。尽管皮肤比其他任何器官更自然地暴露于光线下，但它对红色和近红外波长仍有良好反应。光子被皮肤细胞中的线粒体发色团吸收。因此，电子传递、三磷酸腺苷一氧化氮释放、血流量、活性氧增加，并且多种信号通路被激活。干细胞可以被激活，从而促进组织修复和愈合。在皮肤科，LLLT对皱纹、痤疮疤痕、增生性疤痕和烧伤愈合有有益作用。LLLT作为一种治疗方法和预防措施都可以减少紫外线损伤。在白癜风等色素沉着紊乱疾病中，LLLT可以通过刺激黑素细胞增殖增加色素沉着，并通过抑制自身免疫减少色素脱失。银屑病和痤疮等炎症性疾病也可以得到治疗。其非侵入性本质以及几乎完全没有副作用促使其在皮肤科进行进一步测试。
