Zidek W, Losse H, Lange-Asschenfeldt H, Vetter H
Clin Sci (Lond). 1985 Jan;68(1):45-7. doi: 10.1042/cs0680045.
In 25 patients with untreated essential hypertension and 25 healthy controls, erythrocyte intracellular Cl- concentration and activity as well as Na+ activity were measured. Intracellular Cl- concentration in essential hypertensive patients was 70.6 +/- 11.3 as compared with 84.4 +/- 9.5 mmol/l in the controls (P less than 0.001). Intracellular Cl- activity was 77.5 +/- 13.0 mmol/l of cell water in hypertensive patients, the control value being 100.8 +/- 11.0 mmol/l of cell water (P less than 0.001). In the hypertensive group intracellular Na+ activity was 14.3 +/- 4.1 as compared with 7.1 +/- 1.8 mmol/l of cell water in the normotensive group (P less than 0.01). From these results it is suggested that in essential hypertension not only disturbances of cation metabolism, but also of anion metabolism, occur. Possibly the Cl- changes reflect a decreased Cl- inward transport due to an altered Na-K cotransport.
对25例未经治疗的原发性高血压患者和25例健康对照者测量了红细胞内氯离子浓度、活性以及钠离子活性。原发性高血压患者的细胞内氯离子浓度为70.6±11.3，而对照组为84.4±9.5mmol/L（P<0.001）。高血压患者细胞内氯离子活性为77.5±13.0mmol/L细胞内液，对照值为100.8±11.0mmol/L细胞内液（P<0.001）。高血压组细胞内钠离子活性为14.3±4.1，而血压正常组为7.1±1.8mmol/L细胞内液（P<0.01）。从这些结果提示，在原发性高血压中不仅存在阳离子代谢紊乱，也存在阴离子代谢紊乱。氯离子变化可能反映了由于钠钾协同转运改变导致的氯离子内向转运减少。
