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利用自行构建的X染色体多插入/缺失panel探究贵州苗族和布依族群体的法医效能及群体遗传分化

Exploring the forensic effectiveness and population genetic differentiation in Guizhou Miao and Bouyei group by the self-constructed panel of X chromosomal multi-insertion/deletions.

作者信息

Huang Xiaolan, Gu Changyun, Ran Qianchong, Chen Li, Tian Shunyi, Zhong Min, Ren Zheng, Wang Qiyan, Yang Meiqing, Ji Jingyan, Wan Wen, Huang Jiang, Zhang Hongling, Jin Xiaoye

机构信息

Department of Forensic Medicine, Guizhou Medical University, Guiyang, Guizhou, 550025, China.

School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou, 550025, China.

出版信息

BMC Genomics. 2024 Dec 9;25(1):1185. doi: 10.1186/s12864-024-11088-2.

DOI:10.1186/s12864-024-11088-2
PMID:39648202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11626752/
Abstract

In this research, a self-developed panel comprising 22 X chromosomal multi-InDels and one X-STR was used to explore the genetic polymorphisms and forensic characteristics of these loci in Guizhou Miao and Guizhou Bouyei populations. Besides, genetic affiliations among Guizhou Miao, Guizhou Bouyei and Guizhou Han populations were investigated using principal component analysis, STRUCTURE and machine learning methods. The findings indicated that these loci in the male and female samples had comprehensive discrimination powers greater than 0.999999999. Meanwhile, the cumulative mean exclusion chance of these 23 loci for trio and duo cases were also greater than 0.9999 in Guizhou Miao and Guizhou Bouyei populations. Population genetic analyses of three Guizhou populations revealed that there were relatively low genetic divergences among these populations based on the self-constructed panel. In conclusion, this system could be utilized as the valuable tool for forensic personal identification and parentage testing in Guizhou Miao and Guizhou Bouyei populations.

摘要

在本研究中，使用一个自行开发的包含22个X染色体多插入缺失和1个X-STR的检测板，来探究这些基因座在贵州苗族和贵州布依族人群中的遗传多态性和法医学特征。此外，还运用主成分分析、STRUCTURE软件和机器学习方法，研究了贵州苗族、贵州布依族和贵州汉族人群之间的遗传关系。研究结果表明，这些基因座在男性和女性样本中的综合鉴别力均大于0.999999999。同时，在贵州苗族和贵州布依族人群中，这23个基因座对三联体和二联体案件的累积平均排除率也大于0.9999。对贵州三个民族的群体遗传学分析显示，基于自行构建的检测板，这些人群之间的遗传差异相对较小。总之，该系统可作为贵州苗族和贵州布依族人群法医学个体识别和亲子鉴定的有价值工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f465/11626752/dffeab04215b/12864_2024_11088_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f465/11626752/129d19a756fa/12864_2024_11088_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f465/11626752/673a8ab91f01/12864_2024_11088_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f465/11626752/dffeab04215b/12864_2024_11088_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f465/11626752/129d19a756fa/12864_2024_11088_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f465/11626752/673a8ab91f01/12864_2024_11088_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f465/11626752/dffeab04215b/12864_2024_11088_Fig3_HTML.jpg

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Forensic features and phylogenetic structure survey of four populations from southwest China the autosomal insertion/deletion markers.中国西南四个群体常染色体插入/缺失标记的法医特征及系统发育结构调查
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