Wang Jing, Yuan Qiang, Hu Weitao, Ye Zhijun, Zhang Li, Wang Zhipeng, Liu Jiejun, Huang Ling, Liu Fasheng, Liao Xinjun, Xiao Juhua, Zhang Shouhua, Cao Zigang
Affiliated Hospital of Jinggangshan University, Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, Clinical Research Center of Affiliated Hospital of Jinggangshan University, College of Life Sciences, Jinggangshan University, Ji'an, China.
Affiliated Hospital of Jinggangshan University, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Ji'an, Jiangxi Province, China.
Environ Toxicol. 2025 Apr;40(4):664-673. doi: 10.1002/tox.24440. Epub 2024 Dec 8.
Numerous contemporary diseases are linked to food contamination. Pathogenic agents might stem from certain food ingredients or result from pollution stemming from food processing or packaging. One such contaminant is 3-Chloro-1,2-propanediol (3-MCPD), it has been previously reported to be produced during the preparation of chemical sauces, as well as during the heating of baked goods. Yet, uncertainty surrounds its potential to induce embryonic developmental toxicity. In this study, zebrafish were employed as the focal point to assess the impact of 3-MCPD on initial embryonic development, heart functionality, and behavior. The research unveiled that exposure of zebrafish embryos to 18, 36, and 54 mM 3-MCPD led to cardiac anomalies, including pericardial edema, reduced heart rate, and elongated SV-BA distance. Additionally, 3-MCPD exposure triggered aberrations in cardiac-related gene expression and an elevation in oxidative stress. Notably, behavioral changes were observed in 3-MCPD-exposed zebrafish embryos, while vascular development appeared unaffected. This study introduces a novel basis for comprehensive exploration of 3-MCPD toxicity.
许多当代疾病都与食品污染有关。病原体可能源于某些食品成分，也可能源于食品加工或包装过程中的污染。一种这样的污染物是3-氯-1,2-丙二醇（3-MCPD），此前有报道称它在化学调味汁的制备过程中以及烘焙食品加热过程中产生。然而，其诱发胚胎发育毒性的可能性仍存在不确定性。在本研究中，以斑马鱼为重点评估3-MCPD对胚胎早期发育、心脏功能和行为的影响。研究发现，将斑马鱼胚胎暴露于18、36和54 mM的3-MCPD会导致心脏异常，包括心包水肿、心率降低和SV-BA距离延长。此外，3-MCPD暴露引发了心脏相关基因表达的异常和氧化应激的升高。值得注意的是，在暴露于3-MCPD的斑马鱼胚胎中观察到了行为变化，而血管发育似乎未受影响。本研究为全面探索3-MCPD毒性引入了新的依据。
