Wang Haoyu, Han Jiahang, Wang Zewei, Zhou Haiying, Alhaskawi Ahmad, Dong Yanzhao, Lu Hui
Departments of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, P.R. China.
Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, P.R. China.
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241287087. doi: 10.1177/15330338241287087.
Non-subungual glomus tumor in the fingers is very rare. To explore the insights gained from diagnosing and treating non-subungual glomus tumors in the finger, we collected 19 cases in the last ten years, which were only reported as isolated cases in the previous literature. This was a retrospective study of 19 surgical patients between May 2012 and January 2022 with preoperative MRI, ultrasound, and their final pathological diagnosis is glomus tumor, while the lesions were located not under the nail bed. Immunohistochemistry indicated that SMA(+)100%, CD34(+)89.5%, Ki-67(+1∼3%)68.4%, CD31(vessel+)26.3%, Desmin(+)21%, Calponin(+) 10.5%, Vimentin(+)5.2%, Caldesmon(+)5.2%. The sensitivity of preoperative MRI was 100%, while the sensitivity of ultrasound was 63.2%. And the diagnosing accuracy rate of preoperative MRI was 36.8%. Preoperative MRI is helpful in the diagnosis of non-subungual glomus tumor in fingers. Ultrasound can be used as a supplemental examination technique, and the results depend on the operator and tumor location. Surgical excision is an effective therapy for non-subungual GT in the fingers.
手指非甲下血管球瘤非常罕见。为探讨手指非甲下血管球瘤的诊断与治疗经验,我们收集了过去十年间的19例病例,此前文献仅将其作为孤立病例报道。这是一项对2012年5月至2022年1月期间19例手术患者的回顾性研究,术前均行MRI、超声检查,最终病理诊断为血管球瘤,病变位于非甲床部位。免疫组化结果显示:平滑肌肌动蛋白(SMA)阳性率100%,CD34阳性率89.5%,Ki-67阳性率(1%~3%)68.4%,CD31(血管阳性)阳性率26.3%,结蛋白(Desmin)阳性率21%,钙调蛋白(Calponin)阳性率10.5%,波形蛋白(Vimentin)阳性率5.2%,钙结合蛋白(Caldesmon)阳性率5.2%。术前MRI的敏感性为100%,超声的敏感性为63.2%。术前MRI的诊断准确率为36.8%。术前MRI有助于手指非甲下血管球瘤的诊断。超声可作为补充检查技术,其结果取决于操作者及肿瘤位置。手术切除是治疗手指非甲下血管球瘤的有效方法。