Boopathi Thangavel, Manimaran Sekar, Kerena Joseline Charles, Sebeena Mathew, Karthick Kumaravadivel, Deepa Natesan Thangaraj
Department of Conservative Dentistry and Endodontics, KSR Institute of Dental Science and Research, Tiruchengode, TN, India.
Restor Dent Endod. 2024 Oct 29;49(4):e39. doi: 10.5395/rde.2024.49.e39. eCollection 2024 Nov.
This study aimed to comparatively assess the histological response of the pulp toward alendronate and Biodentine in a direct pulp capping procedure.
Twenty-four anterior teeth from 6 New Zealand rabbits were used in this study. Firstly, all rabbits were anesthetized according to their weight. Class V cavities were prepared on the buccal surfaces of anterior teeth. A pin-point exposure of the pulp was then made using a small, sterile round carbide bur and bleeding was arrested with a saline-soaked, sterile cotton pellet. The teeth under study were divided into 2 groups ( = 12). The intentionally exposed pulp was capped with alendronate (Group 1) and Biodentine (Group 2), correspondingly. After 30 days, all rabbits were euthanized; the teeth under study were extracted and taken up for histological analysis.
Biodentine showed an intact, very dense dentin bridge formation with a uniform odontoblast (OD) layer pattern and mild or absent inflammatory response whereas specimens capped with alendronate demonstrated a dense dentin bridge formation with non-uniform OD layer pattern and mild to moderate inflammatory response.
Biodentine showed more biocompatibility than alendronate. However, alendronate can initiate reparative dentin formation and may be used as an alternative pulp capping agent.
本研究旨在比较评估在直接盖髓术中牙髓对阿仑膦酸盐和生物活性玻璃陶瓷（Biodentine）的组织学反应。
本研究使用了6只新西兰兔的24颗前牙。首先，根据兔子体重对所有兔子进行麻醉。在前牙颊面制备V类洞。然后用小型无菌圆形硬质合金车针造成牙髓的点状暴露，并用浸有生理盐水的无菌棉球止血。将受试牙齿分为2组（每组n = 12）。相应地，用阿仑膦酸盐（第1组）和生物活性玻璃陶瓷（第2组）覆盖故意暴露的牙髓。30天后，对所有兔子实施安乐死；拔出受试牙齿并进行组织学分析。
生物活性玻璃陶瓷显示形成完整、非常致密的牙本质桥，成牙本质细胞（OD）层模式均匀，炎症反应轻微或无炎症反应，而用阿仑膦酸盐覆盖的标本显示形成致密的牙本质桥，OD层模式不均匀，炎症反应轻度至中度。
生物活性玻璃陶瓷比阿仑膦酸盐表现出更高的生物相容性。然而，阿仑膦酸盐可引发修复性牙本质形成，可作为一种替代的盖髓剂。
