Freitas da Silva Carolina, Bernardino-Neto Morun, Fidale Thiago Montes, Monteiro de Magalhães Neto Anibal, Valentim-Silva João Rafael, Karaccas de Carvalho Yuri, Raimundo Rodrigo Daminello, de Abreu Luiz Carlos, Martins Silva Romeu Paulo, Penha-Silva Nilson
Institute of Biotechnology, Federal University of Catalão, Catalão, GO, Brazil.
Postgraduate Program in Health Sciences of the Western Amazon, Federal University of Acre, Rio Branco, AC, Brazil.
Sports Med Health Sci. 2023 Dec 29;7(1):28-36. doi: 10.1016/j.smhs.2023.12.007. eCollection 2025 Jan.
Prolonged hyperglycemia conditions are a risk factor for chronic degenerative diseases such as diabetes and obesity. Testosterone is known to cause muscle hypertrophy, reduced fat mass, and increased body strength. The study aimed to verify possible alterations and differences in the influence of testosterone on the physical performance in post-exercise conditions of young and old animals with alloxan-induced hyperglycemia. We randomly assigned 32 young Wistar rats to groups of untreated non-diabetic young, treated non-diabetic young, untreated diabetic young, and treated diabetic young rats, and 32 aged Wistar rats to groups of untreated non-diabetic elderly, treated non-diabetic elderly, untreated diabetic elderly, and treated diabetic elderly rats, with eight animals each group. The treated non-diabetic and treated diabetic groups received injections of 15 mg/kg weight Durateston™. All the trained groups performed aquatic training with an overload of 5% of the body mass. Following the experiment, we anesthetized and euthanized the animals after exercise (exhaustion). Hemoglobin, erythrocytes, and hematocrit values were higher in the treated groups. The treated diabetic elderly group had the highest leukocyte and neutrophil counts compared to the untreated young groups ( < 0.05). As for the lipid profile, untreated rats had the highest values. Glucose concentration was higher at rest and after exercise in the untreated diabetic groups ( < 0.05). Lactate was more elevated in the untreated diabetic groups, and the testosterone-treated groups performed the longest swimming time after the maximal test ( < 0.05). The use of testosterone in conjunction with physical exercise improved physical performance in water, blood glucose, and lipid profiles.
长期高血糖状况是糖尿病和肥胖症等慢性退行性疾病的一个风险因素。已知睾酮会导致肌肉肥大、脂肪量减少和身体力量增加。该研究旨在验证在四氧嘧啶诱导的高血糖年轻和老年动物运动后的情况下，睾酮对身体机能影响的可能变化和差异。我们将32只年轻的Wistar大鼠随机分为未治疗的非糖尿病年轻组、治疗的非糖尿病年轻组、未治疗的糖尿病年轻组和治疗的糖尿病年轻大鼠组，以及将32只老年Wistar大鼠随机分为未治疗的非糖尿病老年组、治疗的非糖尿病老年组、未治疗的糖尿病老年组和治疗的糖尿病老年大鼠组，每组8只动物。治疗的非糖尿病组和治疗的糖尿病组接受15毫克/千克体重的长效睾酮（Durateston™）注射。所有训练组进行了5%体重过载的水上训练。实验结束后，我们在运动（疲劳）后对动物进行麻醉并处死。治疗组的血红蛋白、红细胞和血细胞比容值较高。与未治疗的年轻组相比，治疗的糖尿病老年组的白细胞和中性粒细胞计数最高（P<0.05）。至于血脂情况，未治疗的大鼠血脂值最高。未治疗的糖尿病组在休息时和运动后的血糖浓度较高（P<0.05）。未治疗的糖尿病组乳酸水平升高更明显，而睾酮治疗组在最大测试后的游泳时间最长（P<0.05）。睾酮与体育锻炼结合使用可改善水中的身体机能、血糖和血脂情况。
