Vermeersch A S, Van Nieuwerburgh F, Gansemans Y, Ali M, Ducatelle R, Geldhof P, Deforce D, Callens J, Opsomer G
Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
Laboratory of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium.
JDS Commun. 2024 Mar 29;5(6):598-601. doi: 10.3168/jdsc.2023-0537. eCollection 2024 Nov.
Udder cleft dermatitis is a skin disease in dairy cattle that is characterized by painful, large open wounds between the udder halves or at the front udder attachment. Its impact on animal welfare and production warrants an in-depth investigation of its pathogenesis. The present study delves into the pathophysiology of severe udder cleft dermatitis, employing a multi-omics approach by integrating transcriptomic and metagenomic data obtained from samples of severe udder cleft dermatitis lesions and healthy udder skin of dairy cattle. All dominant features selected from the virulence factor, taxonomic, and transcriptomic datasets, except for the facultative pathogen , form a network that could be associated with the healthy udder skin. The severe udder cleft dermatitis-associated exhibited a negative correlation with these virulence factors and genes, but was not correlated with the other commensal bacteria in the analysis. Examining the different components interacting with each other could advance our understanding of the pathogenesis of severe udder cleft dermatitis.
乳房裂皮炎是奶牛的一种皮肤病，其特征是乳房两半之间或乳房前部附着处出现疼痛的、大的开放性伤口。它对动物福利和生产的影响值得对其发病机制进行深入研究。本研究通过整合从患有严重乳房裂皮炎病变的奶牛样本和健康乳房皮肤中获得的转录组和宏基因组数据，采用多组学方法深入探究严重乳房裂皮炎的病理生理学。从毒力因子、分类学和转录组数据集中选择的所有主要特征，除了兼性病原菌外，形成了一个可能与健康乳房皮肤相关的网络。与严重乳房裂皮炎相关的[具体内容缺失]与这些毒力因子和基因呈负相关，但在分析中与其他共生细菌无关。研究相互作用的不同成分可以增进我们对严重乳房裂皮炎发病机制的理解。
