Huerta-Uribe Nidia, Hormazábal-Aguayo Ignacio, Muñoz-Pardeza Jacinto, Chueca-Guindulain María J, Berrade-Zubiri Sara, Sesma Carlos Andrés, Sánchez Elisabet Burillo, Ezzatvar Yasmin, Yáñez-Sepúlveda Rodrigo, Izquierdo Mikel, García-Hermoso Antonio
Navarrabiomed, Hospital Universitario de Navarra, IdiSNA, Universidad Pública de Navarra, Pamplona, Spain.
Pediatric Endocrinology Unit, Department of Pediatrics, IdiSNA, Hospital Universitario de Navarra, Pamplona, Spain.
BMJ Open Sport Exerc Med. 2024 Dec 4;10(4):e002177. doi: 10.1136/bmjsem-2024-002177. eCollection 2024.
This study aimed to explore the association between handgrip strength, cardiometabolic risk (CMR) and body composition in youth with type 1 diabetes.
For this prospective cohort study, muscular fitness was assessed via handgrip test and relativised by weight, and body composition, evaluated through dual-energy X-ray absorptiometry in type 1 diabetes patients aged 6-18 years. CMR score included z-scores for total body fat, blood pressure, glycated haemoglobin (HbA1c), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride-glucose index.
Eighty-three patients were analysed at baseline and 1-year follow-up (44.6% females, mean age 12.77 years). Individuals with high handgrip strength tended to have lower CMR and body fat compared with those with low handgrip strength. Over a year, individuals with high handgrip strength showed reduced HbA1c, CMR and subcutaneous fat. Consistently meeting high handgrip strength criteria resulted in reductions in HbA1c levels, CMR score and subcutaneous adipose tissue compared with those who never complied or lost compliance during follow-up. Additionally, subjects classified with high handgrip strength both at baseline and follow-up had a lower likelihood of being classified with high CMR (OR=0.241, 95% CI 0.121 to 0.947, p=0.044).
High handgrip strength was associated with significant cardiometabolic and body composition benefits in youth with type 1 diabetes. This tool could be considered of potential clinical value for incorporating assessments like handgrip tests to monitor and address cardiometabolic health.
本研究旨在探讨1型糖尿病青少年的握力、心脏代谢风险（CMR）与身体成分之间的关联。
在这项前瞻性队列研究中，通过握力测试评估肌肉健康状况，并按体重进行标准化，通过双能X线吸收法评估6至18岁1型糖尿病患者的身体成分。CMR评分包括全身脂肪、血压、糖化血红蛋白（HbA1c）、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯-葡萄糖指数的z评分。
在基线和1年随访时对83例患者进行了分析（44.6%为女性，平均年龄12.77岁）。与握力低的个体相比，握力高的个体往往CMR和体脂较低。在一年时间里，握力高的个体HbA1c、CMR和皮下脂肪减少。与随访期间从未达到或失去达标的个体相比，持续达到高握力标准导致HbA1c水平、CMR评分和皮下脂肪组织减少。此外，在基线和随访时均被分类为握力高的受试者被分类为高CMR的可能性较低（OR=0.241，95%CI 0.121至0.947，p=0.044）。
高握力与1型糖尿病青少年显著的心脏代谢和身体成分益处相关。该工具可被认为具有潜在的临床价值，可纳入握力测试等评估以监测和解决心脏代谢健康问题。
