Drucker D J, Bookman A A
Can Med Assoc J. 1985 Jan 15;132(2):147-9.
Pseudotumour cerebri is a disorder characterized by elevated intracranial pressure in the absence of hydrocephalus and intracranial mass lesions. The cause of this disease remains obscure but has been related to diverse underlying conditions. We report a patient with pseudotumour cerebri, polyarthritis, urticaria, hypocomplementemia and cryoglobulinemia. Serial lumbar punctures were unsuccessful in lowering the cerebrospinal fluid (CSF) pressure. A trial of prednisone, 40 mg daily for 4 weeks, resulted in clinical improvement but was ineffective in lowering the CSF pressure. Circulating immune complexes and complement activation may have played a role in the development of increased intracranial pressure. Cryoglobulinemia should be added to the list of disorders associated with pseudotumour cerebri.
假性脑瘤是一种在无脑积水和颅内占位性病变的情况下以颅内压升高为特征的疾病。该病病因尚不清楚，但与多种潜在疾病有关。我们报告了一名患有假性脑瘤、多关节炎、荨麻疹、低补体血症和冷球蛋白血症的患者。多次腰椎穿刺未能降低脑脊液压力。每日服用40毫克泼尼松，持续4周的试验使临床症状有所改善，但对降低脑脊液压力无效。循环免疫复合物和补体激活可能在颅内压升高的发生中起了作用。冷球蛋白血症应被列入与假性脑瘤相关的疾病名单中。
