Wang Jiang, Xie Fayi, Zhu Wan, Ye Dongmei, Xiao Yi, Shi Mengxia, Zeng Rui, Bian Jiahui, Xu Xiao, Chen Lihuan, Zhu Aizhang, Zhu Ke, Fan Tenghui, Liu Bin, Xiao Liyan, Zhang Xiaoming
School of Basic Medicine, Jinggangshan University, Ji'an, China.
Online Collaborative Research Center for Evidence-Based Medicine Ministry of Education, Jinggangshan University, Ji'an, China.
Front Nutr. 2024 Nov 22;11:1479994. doi: 10.3389/fnut.2024.1479994. eCollection 2024.
Previous researches have demonstrated an association between carotenoids and elongated telomeres. Nonetheless, there is scant scientific evidence examining this relationship in individuals who are overweight or obese, a demographic more predisposed to accelerated aging. This study aims to elucidate the correlation between serum carotenoid concentrations and telomere length within this population group.
Data were sourced from the 2001-2002 National Health and Nutrition Examination Survey, encompassing 2,353 overweight or obese participants. The levels of -carotene, -carotene (both trans and cis isomers), -cryptoxanthin, lutein/zeaxanthin, and trans-lycopene were quantified via high-performance liquid chromatography. Telomere length was assessed using quantitative polymerase chain reaction.
Following adjustment for potential confounders, telomere length exhibited an increase of 1.83 base pairs (bp) per unit elevation in -carotene levels ( = 1.83; 95% CI: 0.48, 3.18). Within the fully adjusted model, telomere length incremented by 1.7 bp per unit increase in serum -carotene among overweight individuals ( = 1.7; 95% CI: 0.1, 3.3), and by 2.6 bp per unit increase among obese individuals ( = 2.6; 95% CI: 0.1, 5.0). Furthermore, restricted cubic spline analysis revealed a linear relationship between -carotene levels and telomere length, whereas a non-linear association was observed between -cryptoxanthin levels and telomere length.
This investigation indicates that higher serum -carotene concentrations are linked with extended telomere length in overweight and obese populations in the United States. These findings warrant further validation through prospective studies.
先前的研究已证明类胡萝卜素与延长的端粒之间存在关联。然而，在超重或肥胖个体（这一更容易加速衰老的人群）中，检验这种关系的科学证据却很少。本研究旨在阐明该人群中血清类胡萝卜素浓度与端粒长度之间的相关性。
数据来源于2001 - 2002年全国健康与营养检查调查，涵盖2353名超重或肥胖参与者。通过高效液相色谱法定量测定α-胡萝卜素、β-胡萝卜素（包括反式和顺式异构体）、β-隐黄质、叶黄素/玉米黄质以及反式番茄红素的水平。使用定量聚合酶链反应评估端粒长度。
在对潜在混杂因素进行调整后，α-胡萝卜素水平每升高一个单位，端粒长度增加1.83个碱基对（bp）（β = 1.83；95%置信区间：0.48，3.18）。在完全调整模型中，超重个体血清β-胡萝卜素每增加一个单位，端粒长度增加1.7 bp（β = 1.7；95%置信区间：0.1，3.3），肥胖个体中每增加一个单位端粒长度增加2.6 bp（β = 2.6；95%置信区间：0.1，5.0）。此外，受限立方样条分析显示α-胡萝卜素水平与端粒长度之间存在线性关系，而β-隐黄质水平与端粒长度之间观察到非线性关联。
本调查表明，在美国超重和肥胖人群中，较高的血清α-胡萝卜素浓度与更长的端粒长度相关。这些发现需要通过前瞻性研究进一步验证。
